This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Microbial Adhesion vs Tissue Integration

Anthony G. Gristina, MD; Joanne J. Dobbins, PhD; Beverly Giammara, MS; Jon C. Lewis, PhD; William C. DeVries, MD

JAMA. 1988;259(6):870-874.

Abstract
The principal barrier to the extended use of the total artificial heart is infection that is centered on the biomaterial constituting the prosthetic device and exacerbated by the surrounding damaged tissue. Ultrastructural studies of total artificial hearts removed from two patients indicate a failure of true tissue integration and diffuse, adhesive bacterial colonization of biomaterial surfaces. Biomaterials are, in part, susceptible to infection because, at the present state of the art, they are usually not well integrated with host tissue or, if hemodynamic, not optimally biocompatible or antiadhesive.

(JAMA 1988;259:870-874)

Author Affiliations
From the Section of Orthopedic Surgery (Dr Gristina) and Department of Pathology (Dr Lewis), Wake Forest University Medical Center, Winston-Salem, NC; the Department of Biology Bellarmine College (Dr Dobbins), the Graduate Programs and Research, University of Louisville (Ms Giammara), and Humana Heart Institute International (Dr DeVries), Louisville.

Footnotes
Reprint requests to Section of Orthopedic Surgery, Wake Forest University Medical Center, 300 S Hawthorne Rd, Winston-Salem, NC 27103 (Dr Gristina).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Periodontitis: An Archetypical Biofilm Disease
Schaudinn et al.
Journal of the American Dental Association 2009;140:978-986.
ABSTRACT | FULL TEXT  

Microbial Biofilms in Ophthalmology and Infectious Disease
Behlau and Gilmore
Arch Ophthalmol 2008;126:1572-1581.
ABSTRACT | FULL TEXT  

Total Artificial Heart
Frazier et al.
Card Surg Adult 2008;3:1629-1638.
FULL TEXT  

Total Artificial Heart
Frazier et al.
Card Surg Adult 2003;2:1507-1514.
FULL TEXT  

Microbial Biofilms: from Ecology to Molecular Genetics
Davey and O'toole
Microbiol. Mol. Biol. Rev. 2000;64:847-867.
ABSTRACT | FULL TEXT  

Hydrogen peroxide for prevention of bacterial growth on polymer biomaterials
Alt et al.
Ann. Thorac. Surg. 1999;68:2123-2128.
ABSTRACT | FULL TEXT  

Antibiotic susceptibility assay for Staphylococcus aureus in biofilms developed in vitro
Amorena et al.
J Antimicrob Chemother 1999;44:43-55.
ABSTRACT | FULL TEXT  

Defensins Impair Phagocytic Killing by Neutrophils in Biomaterial-Related Infection
Kaplan et al.
Infect. Immun. 1999;67:1640-1645.
ABSTRACT | FULL TEXT  

Infections During Extended Circulatory Support: University of Alabama at Birmingham Experience 1989 to 1994
Holman et al.
Ann. Thorac. Surg. 1996;61:366-371.
ABSTRACT | FULL TEXT  

The Permanent Artificial Heart: Four Case Reports
DeVries
JAMA 1988;259:849-859.
ABSTRACT  

Artificial Heart Implantation: What Limitations Are Imposed by Infectious Complications?
Rice and Karchmer
JAMA 1988;259:894-895.
ABSTRACT