This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Scott D. Holmberg, MD; John A. Stewart, MD; A. Russell Gerber, MD; Robert H. Byers, PhD; Francis K. Lee, PhD; Paul M. O'Malley; Andre J. Nahmias, MD

JAMA. 1988;259(7):1048-1050.

Abstract
Antibodies to cytomegalovirus (CMV), Epstein-Barr virus (EBV), and herpes simplex viruses types 1 and 2 (HSV-1, HSV-2) in three sequential serum samples from 62 men who did and 61 men who did not develop human immunodeficiency virus (HIV) infection at the time of the final (third) serum specimen were studied. Antibody titers to CMV, EBV, and HSV-1 did not significantly rise in or differ between men who did or did not get HIV infection. However, we found that 32 (68%) of 47 HIV seroconverters had antibodies to HSV-2 at the time the third specimen was drawn, whereas only 26 (46%) of 57 men who remained HIV seronegative had HSV-2 antibody positivity. Seroconversion to HSV-2 between any two serum specimens was found in 11 (42%) of the 26 HIV seroconverters but in only five (14%) of 35 men who remained HIV seronegative. The association between HSV-2 seropositivity (or seroconversion) and subsequent or concurrent HIV seroconversion remained when we controlled for factors known to influence HIV infection, including age, number of sexual partners, and percentage of sexual acts involving receptive anal intercourse. These serologic studies do not support the role of CMV, EBV, or HSV-1 in HIV infection but do suggest that HSV-2 infection is a risk factor for subsequent or concurrent HIV infection.

(JAMA 1988;259:1048-1050)

Author Affiliations
From the AIDS Program and the Division of Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, Department of Health and Human Services (Drs Holmberg, Stewart, and Byers), and the Department of Pediatrics, Emory University School of Medicine (Drs Gerber, Lee, and Nahmias), Atlanta; and the San Francisco Department of Health (Mr O'Malley).

Footnotes
Reprint requests to AIDS Program, Bldg 6-274, Mail-stop G22, Centers for Disease Control, Atlanta, GA 30333 (Dr Holmberg).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

A Replication-Competent, Neuronal Spread-Defective, Live Attenuated Herpes Simplex Virus Type 1 Vaccine
Brittle et al.
J. Virol. 2008;82:8431-8441.
ABSTRACT | FULL TEXT  

Herpes simplex virus type 2: epidemiology and management options in developing countries
Paz-Bailey et al.
Postgrad. Med. J. 2008;84:299-306.
ABSTRACT | FULL TEXT  

Herpes simplex virus type 2: epidemiology and management options in developing countries
Paz-Bailey et al.
Sex. Transm. Infect. 2007;83:16-22.
ABSTRACT | FULL TEXT  

Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States.
Xu et al.
JAMA 2006;296:964-973.
ABSTRACT | FULL TEXT  

Increasing relative prevalence of HSV-2 infection among men with genital ulcers from a mining community in South Africa
Lai et al.
Sex. Transm. Infect. 2003;79:202-207.
ABSTRACT | FULL TEXT  

Efficiency of Reconstitution of Immunoglobulin G from Blood Specimens Dried on Filter Paper and Utility in Herpes Simplex Virus Type-Specific Serology Screening
Hogrefe et al.
CVI 2002;9:1338-1342.
ABSTRACT | FULL TEXT  

STD in Bangladesh's trucking industry: prevalence and risk factors
Gibney et al.
Sex. Transm. Infect. 2002;78:31-36.
ABSTRACT | FULL TEXT  

Prevalence and association between herpes simplex virus types 1 and 2-specific antibodies in attendees at a sexually transmitted disease clinic
Roest et al.
Int J Epidemiol 2001;30:580-588.
ABSTRACT | FULL TEXT  

Sex Differences in Risk Factors for HIV Seroconversion Among Injection Drug Users: A 10-Year Perspective
Strathdee et al.
Arch Intern Med 2001;161:1281-1288.
ABSTRACT | FULL TEXT  

Intranasal Immunization with CpG Oligodeoxynucleotides as an Adjuvant Dramatically Increases IgA and Protection Against Herpes Simplex Virus-2 in the Genital Tract
Gallichan et al.
J. Immunol. 2001;166:3451-3457.
ABSTRACT | FULL TEXT  

Reductions in Herpes Simplex Virus Type 2 Antibody Titers After Cognitive Behavioral Stress Management and Relationships With Neuroendocrine Function, Relaxation Skills, and Social Support in HIV-Positive Men
Cruess et al.
Psychosom. Med. 2000;62:828-837.
ABSTRACT | FULL TEXT  

Strong Decline in Herpes Simplex Virus Antibodies Over Time among Young Homosexual Men Is Associated with Changing Sexual Behavior
Dukers et al.
Am J Epidemiol 2000;152:666-673.
ABSTRACT | FULL TEXT  

Construction, Phenotypic Analysis, and Immunogenicity of a UL5/UL29 Double Deletion Mutant of Herpes Simplex Virus 2
Da Costa et al.
J. Virol. 2000;74:7963-7971.
ABSTRACT | FULL TEXT  

Herpes Serology for Dermatologists
Goldman
Arch Dermatol 2000;136:1158-1161.
ABSTRACT | FULL TEXT  

Genital Herpes and Public Health: Addressing a Global Problem
Corey and Handsfield
JAMA 2000;283:791-794.
ABSTRACT | FULL TEXT  

Relation Between Herpes Simplex Viruses and Human Immunodeficiency Virus Infections
Severson and Tyring
Arch Dermatol 1999;135:1393-1397.
ABSTRACT | FULL TEXT  

Neutrophils Aid in Protection of the Vaginal Mucosae of Immune Mice against Challenge with Herpes Simplex Virus Type 2
Milligan
J. Virol. 1999;73:6380-6386.
ABSTRACT | FULL TEXT  

Recombinant Glycoprotein Vaccine for the Prevention of Genital HSV-2 Infection: Two Randomized Controlled Trials
Corey et al.
JAMA 1999;282:331-340.
ABSTRACT | FULL TEXT  

Genital Herpes: Review of the Epidemic and Potential Use of Type-Specific Serology
Ashley and Wald
Clin. Microbiol. Rev. 1999;12:1-8.
ABSTRACT | FULL TEXT  

Herpes Simplex Virus Type 2 in the United States, 1976 to 1994
Fleming et al.
NEJM 1997;337:1105-1111.
ABSTRACT | FULL TEXT  

Seroprevalence of Herpes Simplex Virus Infections in a Family Medicine Clinic
Oliver et al.
Arch Fam Med 1995;4:228-232.
ABSTRACT  

Preventive Services Guidelines for Primary Care Clinicians Caring for Adults and Adolescents Infected With the Human Immunodeficiency Virus
Gerber et al.
Arch Fam Med 1993;2:969-979.
ABSTRACT  

Prevalence and Correlates of Herpes Simplex Infections: The Population-Based AIDS in Multiethnic Neighborhoods Study
Siegel et al.
JAMA 1992;268:1702-1708.
ABSTRACT  

Association of Human Immunodeficiency Virus and Anal Human Papillomavirus Infection Among Homosexual Men
Critchlow et al.
Arch Intern Med 1992;152:1673-1676.
ABSTRACT  

Efficacy of Nonoxynol 9 Contraceptive Sponge Use in Preventing Heterosexual Acquisition of HIV in Nairobi Prostitutes
Kreiss et al.
JAMA 1992;268:477-482.
ABSTRACT  

The Impact of Human T-Lymphotrophic Virus Type I/II Infection on the Prognosis of Sexually Acquired Cases of Acquired Immunodeficiency Syndrome
Gotuzzo et al.
Arch Intern Med 1992;152:1429-1432.
ABSTRACT  

Effect of HIV Posttest Counseling on STD Incidence
Zenilman et al.
JAMA 1992;267:843-845.
ABSTRACT  

Care of Women Infected With the Human Immunodeficiency Virus
Minkoff and DeHovitz
JAMA 1991;266:2253-2258.
ABSTRACT  

Epidemiology of Primary and Secondary Syphilis in the United States, 1981 Through 1989
Rolfs and Nakashima
JAMA 1990;264:1432-1437.
ABSTRACT  

The Association of Syphilis With Risk of Human Immunodeficiency Virus Infection in Patients Attending Sexually Transmitted Disease Clinics
Quinn et al.
Arch Intern Med 1990;150:1297-1302.
ABSTRACT  

Partner Notification: Can It Control Epidemic Syphilis?
Andrus et al.
ANN INTERN MED 1990;112:539-543.
ABSTRACT  

Acquired Immunodeficiency Syndrome Among Adolescents: Case Surveillance Profiles in New York City and the Rest of the United States
Vermund et al.
Arch Pediatr Adolesc Med 1989;143:1220-1225.
ABSTRACT  

The Influence of HIV Infection on Antibody Responses to a Two-Dose Regimen of Influenza Vaccine
Miotti et al.
JAMA 1989;262:779-783.
ABSTRACT  

Development of Clinically Recognizable Genital Lesions among Women Previously Identified as Having "Asymptomatic" Herpes Simplex Virus Type 2 Infection
Langenberg et al.
ANN INTERN MED 1989;110:882-887.
ABSTRACT  

Relationship of Syphilis to Drug Use and Prostitution-- Connecticut and Philadelphia, Pennsylvania
Arch Dermatol 1989;125:169-170.
ABSTRACT  

Relationship of Syphilis to Drug Use and Prostitution--Connecticut and Philadelphia, Pennsylvania
JAMA 1989;261:353-357.
 

The Perpetual Lessons of Syphilis
Rolfs and Cates
Arch Dermatol 1989;125:107-109.
ABSTRACT  

From the MMWR: Morbidity and Mortality Report Centers for Disease Control, Atlanta
Arch Dermatol 1988;124:1485-1486.
ABSTRACT  

Syphilis and Congenital Syphilis-- United States, 1985-1988
JAMA 1988;260:1533-1534.
 

The Association Between Genital Ulcer Disease and Acquisition of HIV Infection in Homosexual Men
Stamm et al.
JAMA 1988;260:1429-1433.
ABSTRACT  

The Influence of Human Immunodeficiency Virus (HIV) Infection on Antibody Responses to Influenza Vaccines
Nelson et al.
ANN INTERN MED 1988;109:383-388.
ABSTRACT  

Comparison of HIV-Antibody Prevalence in Patients Consenting to and Declining HIV-Antibody Testing in an STD Clinic
Hull et al.
JAMA 1988;260:935-938.
ABSTRACT  

The 'Other STDs': Do They Really Matter?
Cates
JAMA 1988;259:3606-3608.
ABSTRACT