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Kevan E. VanLandingham, MD, PhD; H. Blair Marsteller, MD; Gary W. Ross, MD; Frederick G. Hayden, MD

JAMA. 1988;259(7):1051-1053.

Abstract
Acyclovir sodium is the drug of choice for the treatment of herpes simplex encephalitis. We treated an immunocompetent patient with a ten-day course of intravenous acyclovir sodium at the recommended dosage of 10 mg/kg every eight hours for clinically apparent herpes simplex encephalitis. After marked improvement, his condition deteriorated four days after completing acyclovir therapy. A subsequent brain biopsy specimen disclosed acyclovir-sensitive herpes simplex virus type 1. A longer duration of acyclovir therapy (14 to 21 days) should be considered for treating herpes simplex encephalitis.

(JAMA 1988;259:1051-1053)

Author Affiliations
From the Departments of Neurology (Drs VanLandingham and Marsteller), Internal Medicine (Dr Hayden), and Pathology (Drs Hayden and Ross), University of Virginia School of Medicine, Charlottesville.

Footnotes
Reprint requests to PO Box 473, Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908 (Dr Hayden).

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