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John C. Pottage, Jr, MD; Constance A. Benson, MD; Joel B. Spear, MD; Alan L. Landay, PhD; Harold A. Kessler, MD

JAMA. 1988;260(20):3045-3048.

Abstract
Human immunodeficiency virus (HIV)—related thrombocytopenia has been well described and requires therapy in about one half of the patients. Conventional modes of therapy with prednisone, danazol, immunoglobulin, and/or splenectomy have not been uniformly successful. We have administered zidovudine to three patients with HIV-related thrombocytopenia. All three patients responded with a sustained increase in their platelet counts, despite discontinuation of conventional therapy. Interruption of zidovudine therapy was associated with a decrease in platelet count. Concomitant with the elevation in platelet count with zidovudine therapy, there was a reduction in the circulating p24 antigen levels. Whether the elevations in the platelet count in these patients with HIV-related thrombocytopenia is due to the antiviral effect of zidovudine is unknown. It is clear that further studies examining the prospective use of zidovudine in the treatment of HIV-related thrombocytopenia are indicated.

(JAMA 1988;260:3045-3048)

Author Affiliations
From the Department of Internal Medicine, Section of Infectious Disease (Drs Pottage, Benson, Spear, and Kessler), and the Department of Immunology/Microbiology (Drs Pottage, Landay, and Kessler), Rush-Presbyterian—St Luke's Medical Center, Chicago.

Footnotes
Reprint requests to the Section of Infectious Disease, Rush-Presbyterian—St Luke's Medical Center, 1653 W Congress Parkway, Chicago, IL 60612 (Dr Pottage).

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