This Article  • References  • Full text PDF  • Correction  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Relationships With Cortical Bone Measures

Jane A. Cauley, DPH; James P. Gutai, MD; Lewis H. Kuller, MD, DPH; Dorothea LeDonne; Rivka B. Sandler, PhD; Donald Sashin, PhD; John G. Powell, MS

JAMA. 1988;260(21):3150-3155.

Abstract
To examine the interactions between hormone levels and calcium with cortical bone, we have attempted to combine risk factors for the development of peak skeletal mass with factors that may be related to the maintenance of bone integrity after menopause. A total of 174 postmenopausal women participated in our study. There was little relationship found between androgen hormones and radial bone density. Estrone levels were independently related to radial bone density. Examination of the relationship of calcium intake to bone revealed a protective effect solely in women who reported high "lifetime" calcium intakes. Taking calcium and estrone together revealed an additive relationship between the two factors, in that women with high estrone and high calcium levels had significantly greater bone density than women with less calcium and/or estrone. The results suggest that a lifetime of adequate calcium intake coupled with adequate levels of serum estrogens could maximize bone density after menopause.

(JAMA 1988;260:3150-3155)

Author Affiliations
From the Department of Epidemiology, Graduate School of Public Health (Drs Cauley and Kuller and Ms LeDonne); School of Health Related Professions (Dr Sandler); and the Department of Radiology, School of Medicine (Dr Sashin), University of Pittsburgh; the Department of Pediatrics-Endocrinology, Wayne State University, Detroit (Dr Gutai); and East Carolina School of Medicine, Greenville, NC (Mr Powell).

Footnotes
Reprint requests to the Department of Epidemiology, A525, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261 (Dr Cauley).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Are Breast Density and Bone Mineral Density Independent Risk Factors for Breast Cancer?
Kerlikowske et al.
JNCI J Natl Cancer Inst 2005;97:368-374.
ABSTRACT | FULL TEXT  

Bone Mineral Density and Verbal Memory Impairment: Third National Health and Nutrition Examination Survey
Zhang et al.
Am J Epidemiol 2001;154:795-802.
ABSTRACT | FULL TEXT  

Fracture History and Risk of Breast and Endometrial Cancer
Newcomb et al.
Am J Epidemiol 2001;153:1071-1078.
ABSTRACT | FULL TEXT  

Bone Mass and the Risk of Colon Cancer among Postmenopausal Women : The Framingham Study
Zhang et al.
Am J Epidemiol 2001;153:31-37.
ABSTRACT | FULL TEXT  

Alcohol intake and bone metabolism in elderly women
Rapuri et al.
Am. J. Clin. Nutr. 2000;72:1206-1213.
ABSTRACT | FULL TEXT  

Bone Mineral Density, Androgens, and the Polycystic Ovary: The Complex and Controversial Issue of Androgenic Influence in Female Bone
Zborowski et al.
J. Clin. Endocrinol. Metab. 2000;85:3496-3506.
FULL TEXT  

Bone Mass and the Risk of Breast Cancer among Postmenopausal Women
Zhang et al.
NEJM 1997;336:611-617.
ABSTRACT | FULL TEXT  

Exercise, smoking, and calcium intake during adolescence and early adulthood as determinants of peak bone mass
Valimaki et al.
BMJ 1994;309:230-235.
ABSTRACT | FULL TEXT