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Norbert E. Schindlbeck, MD; Christine Heinrich; Rudolf M. Huber, MD; Stefan A. Müller-Lissner, MD

JAMA. 1988;260(21):3156-3158.

Abstract
Orally or intravenously administered β₂-adrenergic drugs have been found to inhibit esophageal motor function. Since inhalation of these drugs results in less systemic side effects, the present double-blind study was designed to investigate the influence of inhalation of the β₂-adrenergic agonist albuterol (salbutamol) on esophageal motor function and gastroesophageal reflux in ten healthy volunteers. Esophageal motor function was recorded using a pneumohydraulically perfused multilumen manometry tube. Twenty-four—hour pH profiles were measured while the volunteers were ambulatory using a combined glass electrode connected to a portable recorder. Inhalation decreased neither lower esophageal sphincter pressure nor esophageal peristaltic amplitudes. Gastroesophageal reflux was similar on both occasions during inhalation of albuterol (3.1% [range, 1.0% to 25.5%] median upright time, with esophageal pH <4; and 0.1% [range, 0.0% to 10.7%] supine time) and during placebo treatment (3.6% [range, 1.6% to 19.8%] upright and 0.0% [range, 0.0% to 2.5%] supine time). Our data support the study of inhalation of β₂-adrenergic drugs in asthmatic patients with accompanying gastroesophageal reflux.

(JAMA 1988;260:3156-3158)

Author Affiliations
From Medizinische Klinik Innenstadt, University of Munich.

Footnotes
Reprint requests to Medizinische Klinik Innenstadt der Universität, Ziemssenstraβe 1, D-8000 München 2, West Germany (Dr Schindlbeck).

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