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Hyperprolactinemia and Nonpuerperal Mastitis (Duct Ectasia)
Friedolf Peters, MD;
Walter Schuth, MD
JAMA. 1989;261(11):1618-1620.
Abstract
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In 108 patients with nonpuerperal mastitis (inflammatory symptoms of duct ectasia), serum prolactin levels were determined before, during, and after treatment. Twenty-nine patients (26.8%) exhibited transiently elevated prolactin levels during the period of inflammation (mean±SD level, 42 ±22 µg/L that returned to normal within 4 weeks. Twenty-two patients (20.4%) presented with more severe hyperprolactinemia (78 ±56 µg/L), and 15 were found to have pituitary microadenomas. In 11 cases, mastitis was the first symptom of hyperprolactinemia. A second group of 83 patients with known hyperprolactinemia and 83 normoprolactinemic controls were interviewed with regard to recent symptoms or past treatment of nonpuerperal mastitis. Sixteen hyperprolactinemic women (19.3%) and none of the controls reported that they had experienced mastitis. We conclude that duct ectasia is due in part to increased prolactin secretion. Thus, nonpuerperal mastitis may be a symptom of hyperprolactinemia. On the other hand, nonpuerperal mastitis may induce transient hyperprolactinemia (neurogenic hyperprolactinemia) of about 3 weeks' duration that is less pronounced than central hyperprolactinemia.
(JAMA. 1989;261:1618-1620)
Author Affiliations
From the Departments of Obstetrics and Gynecology, University Hospital, Freiburg (Drs Peters and Schuth), and St Hildegardis Hospital, Mainz (Dr Peters), Federal Republic of Germany.
Footnotes
Reprint requests to St Hildegardis-Krankenhaus, Academic Hospital of the Johannes-Gutenberg-University, D-6500 Mainz, West Germany (Dr Peters).
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