This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Brian W. Forsyth; Ralph I. Horwitz; Denise Acampora; Eugene D. Shapiro; Catherine M. Viscoli; Alvan R. Feinstein; Rochelle Henner; Nancy B. Holabird; Beth A. Jones; Artemis D. E. Karabelas; Michael S. Kramer; Michele Miclette; James A. Wells

JAMA. 1989;261(17):2517-2524.

Abstract
To determine the validity of the aspirin/Reye's syndrome association, we developed an epidemiologic investigation to assess the effects of five potential sources of bias. A case-control study incorporated procedures to avoid temporal precedence and susceptibility bias. These included classifying cases as having monophasic or biphasic patterns of illness and matching for severity of symptoms at zero-time. To evaluate the effect of a potential recall bias, an "alternatecondition" control group was enrolled. A medical record review study was conducted to assess the potential for diagnostic bias, and a blanket surveillance of all hospitals in a region was conducted to evaluate reporting bias. Twenty-four case subjects and 48 matched controls were enrolled. Eighty-eight percent of case subjects and only 17% of controls had received aspirin prior to the onset of Reye's syndrome (matched odds ratio, 35; 95% confidence interval, 4.2 to 288). Further analyses demonstrated that the association could not be attributed to the five potential sources of bias.

(JAMA. 1989;261:2517-2524)

Author Affiliations
From the Departments of Pediatrics (B.W. Forsyth, D. Acampora, E. D. Shapiro, R. Henner, N. B. Holabird, B. A. Jones, M. Miclette, and J. A. Wells) and Medicine and Epidemiology (R. I. Horwitz, C. M. Viscoli, and A. R. Feinstein), Yale University School of Medicine, New Haven, Conn; and the Department of Pediatrics, McGill University, Montreal, Canada (A. D. E. Karabelas and M. S. Kramer).

Footnotes
Reprint requests to Yale University School of Medicine, Room IE-61 SHM, PO Box 3333, New Haven, CT 06510 (Dr Horwitz).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Travel and Venous Thrombosis: An Exercise in Thinking About Bias
Vandenbroucke et al.
ANN INTERN MED 2009;151:212-213.
FULL TEXT  

CCR5 and CXCR3 Are Dispensable for Liver Infiltration, but CCR5 Protects against Virus-Induced T-Cell-Mediated Hepatic Steatosis
Holst et al.
J. Virol. 2007;81:10101-10112.
ABSTRACT | FULL TEXT  

Reye syndrome---insights on causation and prognosis
GLASGOW and MIDDLETON
Arch. Dis. Child. 2001;85:351-353.
FULL TEXT  

Lesson of the week: Reye's syndrome and aspirin: lest we forget
McGovern et al.
BMJ 2001;322:1591-1592.
FULL TEXT  

Reye's Syndrome and Salicylate Use, by Karen M. Starko, MD, et al, Pediatrics, 1980;66:859-864; and National Patterns of Aspirin Use and Reye Syndrome Reporting, United States, 1980 to 1985, by Janet B. Arrowsmith et al, Pediatrics, 1987;79:858-863
Kauffman
Pediatrics 1998;102:259-262.
FULL TEXT  

Reye's syndrome
Hall
BMJ 1994;309:411-411.
FULL TEXT  

A Reemergence of Reye's Syndrome
Poss et al.
Arch Pediatr Adolesc Med 1994;148:879-882.
ABSTRACT  

Misdiagnosis of Reye's-like Illness
FORSYTH et al.
Arch Pediatr Adolesc Med 1991;145:964-966.
ABSTRACT