This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Adjunct Therapy to a Prudent Diet for Patients With Mild to Moderate Hypercholesterolemia

Larry P. Bell, MD; Kathy Hectorne; Helenbeth Reynolds, RD; Timothy K. Balm; Donald B. Hunninghake, MD

JAMA. 1989;261(23):3419-3423.

Abstract
Psyllium hydrophilic mucilloid was examined for its ability to lower serum cholesterol levels in hypercholesterolemic patients. Seventy-five patients with mild to moderate hypercholesterolemia were evaluated in this randomized, double-blind, placebo-controlled parallel study. Patients were treated with a Step I diet for 12 weeks before receiving placebo or 3.4 g of psyllium (equivalent to 1 teaspoon) three times per day for 8 weeks. Compared with placebo, psyllium achieved an additional 4.8% reduction in total cholesterol level, 8.2% reduction in low-density lipoprotein cholesterol level, and 8.8% reduction in apolipoprotein B level. Psyllium did not significantly affect blood pressure or levels of high-density cholesterol, triglycerides, serum glucose, or iron. Reported adherence to diet and treatment was excellent, and no significant adverse side effects were noted. These results indicate psyllium hydrophilic mucilloid is an effective and well-tolerated adjunct to diet in the management of mild to moderate hypercholesterolemia.

(JAMA. 1989;261:3419-3423)

Author Affiliations
From the Department of Medicine, University of Minnesota (Drs Bell and Hunninghake and Mss Hectorne and Reynolds), and the Department of Medicine, Hennepin County Medical Center (Dr Bell), Minneapolis; and Health and Personal Care Division, the Procter and Gamble Co, Cincinnati, Ohio (Mr Balm).

Footnotes
Reprint requests to Department of Medicine, Hennepin County Medical Center, 701 Park Ave, Minneapolis, MN 55415 (Dr Bell).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Sex and hormonal status influence plasma lipid responses to psyllium
Vega-Lopez et al.
Am. J. Clin. Nutr. 2001;74:435-441.
ABSTRACT | FULL TEXT  

Long-term cholesterol-lowering effects of psyllium as an adjunct to diet therapy in the treatment of hypercholesterolemia
Anderson et al.
Am. J. Clin. Nutr. 2000;71:1433-1438.
ABSTRACT | FULL TEXT  

Cholesterol-lowering effects of psyllium intake adjunctive to diet therapy in men and women with hypercholesterolemia: meta-analysis of 8 controlled trials1
Anderson et al.
Am. J. Clin. Nutr. 2000;71:472-479.
ABSTRACT | FULL TEXT  

Effects of psyllium on glucose and serum lipid responses in men with type 2 diabetes and hypercholesterolemia
Anderson et al.
Am. J. Clin. Nutr. 1999;70:466-473.
ABSTRACT | FULL TEXT  

Cholesterol-lowering effects of dietary fiber: a meta-analysis
Brown et al.
Am. J. Clin. Nutr. 1999;69:30-42.
ABSTRACT | FULL TEXT  

Psyllium-Enriched Cereals Lower Blood Total Cholesterol and LDL Cholesterol, but Not HDL Cholesterol, in Hypercholesterolemic Adults: Results of a Meta-Analysis
Olson et al.
J. Nutr. 1997;127:1973-1980.
ABSTRACT | FULL TEXT  

Native and Partially Hydrolyzed Psyllium Have Comparable Effects on Cholesterol Metabolism in Rats
Arjmandi et al.
J. Nutr. 1997;127:463-469.
ABSTRACT | FULL TEXT  

Psyllium for the Reduction of Cholestyramine-Associated Gastrointestinal Symptoms in the Treatment of Primary Hypercholesterolemia
Maciejko et al.
Arch Fam Med 1994;3:955-960.
ABSTRACT  

Patient-Directed, Nonprescription Approaches to Cardiovascular Disease
Simon
Arch Intern Med 1994;154:2283-2296.
ABSTRACT  

Effect on Blood Lipids of Very High Intakes of Fiber in Diets Low in Saturated Fat and Cholesterol
Jenkins et al.
NEJM 1993;329:21-26.
ABSTRACT | FULL TEXT  

High-Molecular-Weight Hydroxypropylmethylcellulose: A Cholesterol-Lowering Agent
Dressman et al.
Arch Intern Med 1993;153:1345-NP.
ABSTRACT  

Cholesterol-Lowering Effects oHypercholesterolemiain Patients With Mild to Moderate Hypercholesterolemia
Bell et al.
Arch Intern Med 1992;152:2441-2444.
ABSTRACT  

Hypocholesterolemic Effects of Different Bulk-Forming Hydrophilic Fibers as Adjuncts to Dietary Therapy in Mild to Moderate Hypercholesterolemia
Anderson et al.
Arch Intern Med 1991;151:1597-1602.
ABSTRACT  

The Hypocholesterolemic Effects of {beta}-Glucan in Oatmeal and Oat Bran: A Dose-Controlled Study
Davidson et al.
JAMA 1991;265:1833-1839.
ABSTRACT  

Anaphylaxis Following Ingestion of a Psyllium-Containing Cereal
Lantner et al.
JAMA 1990;264:2534-2536.
ABSTRACT  

On the Formal Induction of the Press Into the Scientific Process
Bausell
Eval Health Prof 1990;13:267-282.
 

Comparison of Psyllium Hydrophilic Mucilloid and Cellulose as Adjuncts to a Prudent Diet in the Treatment of Mild to Moderate Hypercholesterolemia
Levin et al.
Arch Intern Med 1990;150:1822-1827.
ABSTRACT  

DIETARY FIBER LOWERS CHOLESTEROL
JWatch General 1989;1989:5-5.
FULL TEXT