This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Influence of Viral Safety, Cost, and Supply on Therapy

Glenn F. Pierce, MD, PhD; Jeanne M. Lusher, MD; Alan P. Brownstein, MPH, MSW; Jonathan C. Goldsmith, MD; Craig M. Kessler, MD

JAMA. 1989;261(23):3434-3438.

Abstract
Treatment of hemophilia, although greatly improved in recent years, continues to be problematic owing to infectious complications of blood product replacement therapy. This report examines the therapeutic options presently available for the treatment of hemophilia, focusing on the potential for repeated viral exposure to influence the progression of infectious disease, decreased risks of viral transmission with blood products produced using newer viral inactivation procedures, higher economic costs of newer blood products, and the current inadequate supply of blood products in the United States.

(JAMA. 1989;261:3434-3438)

Author Affiliations
From the Departments of Pathology and Medicine, Washington University Medical Center, St Louis, Mo (Dr Pierce); the Department of Pediatrics, Wayne State University School of Medicine, Detroit, Mich (Dr Lusher); the National Hemophilia Foundation, New York, NY (Mr Brownstein); the Department of Medicine, University of Nebraska Medical Center, Omaha (Dr Goldsmith); and the Department of Medicine, George Washington University School of Medicine, Washington, DC (Dr Kessler). Dr Pierce is now with the Department of Experimental Pathology, Amgen, Thousand Oaks, Calif.

Footnotes
Reprint requests to the Division of Hematology-Oncology, George Washington University Medical Center, 2150 Pennsylvania Ave NW, Washington, DC 20037 (Dr Kessler).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

From HMG through purified urinary FSH preparations to recombinant FSH: a substitution study
Zwart-van Rijkom et al.
Hum Reprod 2002;17:857-865.
ABSTRACT | FULL TEXT  

Hemophilia A
Pierce and Rosner
NEJM 1994;330:1617-1617.
FULL TEXT  

Hemophilia A
Hoyer
NEJM 1994;330:38-47.
FULL TEXT  

HIV Testing: State of the Art
Sloand et al.
JAMA 1991;266:2861-2866.
ABSTRACT