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Donald E. Moore, MD; Rhoda L. Ashley, PhD; Paul W. Zarutskie, MD; Robert W. Coombs, MD, PhD; Michael R. Soules, MD; Lawrence Corey, MD

JAMA. 1989;261(23):3441-3443.

Abstract
This report describes a donor in a therapeutic donor insemination program who asymptomatically acquired a primary herpes simplex virus type 2 (HSV-2) infection from his long-standing sexual partner. His fresh semen was used to inseminate two HSV-seronegative recipients; in one a primary HSV-2 infection developed, and in one it did not. Direct evidence of transmission from donor to recipient was documented by restriction enzyme analysis of the HSV-2 isolates obtained from the donor's semen and from the recipient's cervix. Because of the possibility of asymptomatic acquisition and transmission of HSV-2, semen donors and their sexual partners should undergo serologic screening for genital herpes using new, type-specific HSV serologic techniques.

(JAMA. 1989;261:3441-3443)

Author Affiliations
From the Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Washington School of Medicine (Drs Moore, Zarutskie, and Soules), and the Virology Division, Department of Laboratory Medicine, University of Washington (Drs Ashley, Coombs, and Corey), Seattle.

Footnotes
Reprint requests to Department of Obstetrics and Gynecology, RH-20, University of Washington School of Medicine, Seattle, WA 98195 (Dr Moore).

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