 |
|
Effect of Smoking on the Activity of Ischemic Heart Disease
Joan Barry;
Kimberely Mead;
Elizabeth G. Nabel, MD;
Michael B. Rocco, MD;
Stephen Campbell, MB;
Terrence Fenton, EdD;
G. H. Mudge, Jr, MD;
Andrew P. Selwyn, MD
JAMA. 1989;261(3):398-402.
Abstract
| |
Cigarette smoking has been causally linked to coronary heart disease. To investigate the effect of smoking on the activity of ischemic heart disease, 65 patients with chronic stable manifestations of coronary disease and a positive exercise tolerance test underwent continuous ambulatory monitoring to quantify the amount of ischemic ST segment depression during daily life. Twenty-four smokers were compared with 41 nonsmokers for frequency and duration of electrocardiographic signs of ischemia during 24 hours. A total of 4968 hours of ambulatory monitoring were analyzed. The frequency of episodes was three times as often (median) and the duration of ischemia was 12 times longer (median duration, 24 vs 2 min/24 h) in smokers than nonsmokers. This finding remained statistically significant when a number of potentially confounding factors were controlled by means of logistic regression. This study shows that patients with coronary artery disease who smoke have significantly and substantially more active myocardial ischemia during daily life than patients who do not.
(JAMA 1989;261:398-402)
Author Affiliations
From the Cardiovasular Division, Brigham and Women's Hospital, Harvard Medical School (Mss Barry and Mead and Drs Nabel, Rocco, Mudge, and Selwyn), and the Biostatistics Division, Harvard School of Public Health, (Dr Fenton), Boston. Dr Campbell is now with the Radcliffe Infirmary, Oxford (England) University.
Footnotes
Reprint requests to Cardiovascular Division, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115 (Ms Barry).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Columbia University's Informatics for Diabetes Education and Telemedicine (IDEATel) Project: Rationale and Design
Shea et al.
J. Am. Med. Inform. Assoc. 2002;9:49-62.
ABSTRACT
| FULL TEXT
Cooperative Cardiovascular Project (CCP) Quality Improvement in Maine, New Hampshire, and Vermont
Ramunno et al.
Eval Health Prof 1998;21:442-460.
ABSTRACT
Triggers of daily life ischaemia
Freedman and Wong
Heart 1998;80:489-492.
ABSTRACT
| FULL TEXT
Effect of Smoking Status on the Long-Term Outcome after Successful Percutaneous Coronary Revascularization
Hasdai et al.
NEJM 1997;336:755-761.
ABSTRACT
| FULL TEXT
Effects of Cigarette Smoking on the Angiographic Evolution of Coronary Atherosclerosis: A Canadian Coronary Atherosclerosis Intervention Trial (CCAIT) Substudy
Waters et al.
Circulation 1996;94:614-621.
ABSTRACT
| FULL TEXT
North of England evidence based guidelines development project: summary version of evidence based guideline for the primary care management of stable angina
North of England Stable Angina Guideline Developme
BMJ 1996;312:827-832.
FULL TEXT
The Human Costs of Tobacco Use- First of Two Parts
Bartecchi et al.
NEJM 1994;330:907-912.
FULL TEXT
SMOKING INCREASES FREQUENCY OF MYOCARDIAL ISCHEMIA
JWatch General 1989;1989:5-5.
FULL TEXT
Another Smoking Gun Linking Cigarettes and Heart Disease
Cohn
JAMA 1989;261:438-438.
ABSTRACT
|
