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Passive Transfer of HIV Antibody by Hepatitis B Immune Globulin
Walter F. Schlech III, MD, FRCPC;
Spencer H. S. Lee, PhD;
Janice Cook, RN;
Kenneth R. Rozee, PhD;
Nadia MacIntosh, MD
JAMA. 1989;261(3):411-413.
Abstract
Two newborns of mothers carrying hepatitis B and at high risk for human immunodeficiency virus (HIV) infection developed HIV-positive test results by enzyme-linked immunosorbent assay and Western blot tests after birth. Both had been administered hepatitis B immune globulin within 48 hours of birth. Serological tests detected HIV antibody as long as 17 days after birth. Both newborns had received lots of hepatitis B immune globulin containing antibody to HIV. While hepatitis B immune globulin cannot transmit HIV infection to recipients, physicians should be aware that administration of older lots of this preparation may result in transiently positive tests for HIV antibody in the recipients. Lots manufactured from screened plasma do not contain antibody to HIV.
(JAMA 1989;261:411-413)
Author Affiliations
From the Departments of Medicine (Drs Schlech and Macintosh) and Microbiology (Drs Schlech, Lee, and Rozee), Faculty of Medicine, Dalhousie University; and the Infection Control Office, Grace Maternity Hospital (Ms Cook), Halifax, Nova Scotia.
Footnotes
Reprint requests to Victoria General Hospital, 1278 Tower Rd, Halifax, Nova Scotia, Canada B3H 2Y9 (Dr Schlech).
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