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Risk of Developing AIDS in HIV-Infected Cohorts of Hemophilic and Homosexual Men
Janine Jason, MD;
Kung-Jong Lui, PhD;
Margaret V. Ragni, MD;
Nancy A. Hessol, MSPH;
William W. Darrow, PhD
JAMA. 1989;261(5):725-727.
Abstract
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The latency period and/or incidence of the acquired immunodeficiency syndrome (AIDS) may differ in persons infected with the human immunodeficiency virus by different routes or having different "cofactors." We compared 79 hemophilic men in Pennsylvania and 117 homosexual and bisexual men in California, all having known dates of infection and long postinfection observation periods, to examine these hypotheses. By 1987, twenty-one percent of the hemophilic and 27% of the homosexual men had developed AIDS. However, seroconversion patterns differed for the two groups, and when this was taken into account, the conditional odds ratio for AIDS was 1.20. Kaplan-Meier survival analysis showed no significant difference in the cumulative proportion with AIDS, from time of infection. These results are limited by the small size and geographically localized nature of our study populations, but they suggest that currently the relative length of human immunodeficiency virus infection is of primary importance in comparing disease outcome for different populations.
(JAMA 1989;261:725-727)
Author Affiliations
From the Division of Host Factors, Center for Infectious Diseases (Dr Jason), and the Division of Injury Epidemiology and Control, Center for Environmental Health and Injury Control (Dr Lui), Centers for Disease Control, Atlanta; the Department of Medicine, University of Pittsburgh, and Central Blood Bank of Pittsburgh (Dr Ragni); the AIDS Office, Department of Public Health, San Francisco (Ms Hessol); and the AIDS Program, Center for Infectious Diseases, Centers for Disease Control, Atlanta (Dr Darrow).
Footnotes
Reprint requests to the Epidemiology Studies Section, Division of Host Factors, Centers for Disease Control, CID, 1600 Clifton Rd, 1/1343, D02, Atlanta, GA 30333 (Dr Jason).
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