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From Receptor to Contragestion and Beyond

Etienne-Emile Baulieu, MD, PhD

JAMA. 1989;262(13):1808-1814.

Abstract
The steroid RU-486 (mifepristone) is an antiprogesterone that works at the receptor level. It can interrupt pregnancy very early on (contragestion), mostly by interfering with the process of implantation and decidua function. It also may facilitate surgical evacuation of the uterus and certain difficult deliveries. It impedes ovulation when taken during the follicular phase. Also, RU-486 is the first antiglucocorticosteroid available for clinical use. It deserves further studies to assess its wide range of therapeutic potential.

(JAMA. 1989;262:1808-1814)

Author Affiliations
From the Lab Hormones, Institut National de la Santé et de la Recherche Médicale and Faculté de Médecine, Bicêtre, France.; Dr Baulieu is a consultant to Roussel-Uclaf, the manufacturer of RU-486.

Footnotes
Based on a lecture given at the presentation of the Albert Lasker Clinical Medical Research Award, New York, NY, September 27, 1989.

Reprint requests to INSERM U 33, Lab Hormones, 94275 Bicêtre, France.

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