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Alfred G. Gilman, MD, PhD

JAMA. 1989;262(13):1819-1825.

Abstract
The cellular plasma membrane contains highly specialized systems for integration, amplification, and transduction of information that presents itself in the form of extracellular hormones, neurotransmitters, other regulatory molecules, and physical stimuli. A major mechanism for processing this information involves the sequential interactions of three membrane-bound proteins. Receptors for many extracellular regulators bind these molecules and interact with one or more of a family of guanine nucleotide—binding regulatory proteins (G proteins). Conformational alteration of the G protein permits exchange of tightly bound guanosine diphosphate (an inactive ligand) for guanosine triphosphate (the activating ligand). The guanosine triphosphate—bound G protein in turn interacts with intracellular effector molecules, such as adenylyl cyclase, and controls their functions.

(JAMA. 1989;262:1819-1825)

Author Affiliations
From the Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas.

Footnotes
Based on a lecture given at the presentation of the Albert Lasker Basic Medical Research Award, New York, NY, September 27, 1989.

Reprint requests to the Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235-9041 (Dr Gilman).

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