Progress in medical defense against nerve agents
M. A. Dunn and F. R. Sidell
US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Md 21010-5425.
For nearly 50 years, nerve agents have constituted a serious threat that
has stimulated extensive efforts to develop effective medical
countermeasures. Recent progress in producing pharmacologic defenses
suggests that humans can be largely protected from the lethal and prolonged
incapacitating effects of these compounds on a chemical battlefield.
Current research on new approaches to binding and inactivating nerve agents
may further decrease their potential as a threat against protected persons.
Anticonvulsants for Nerve Agent-Induced Seizures: The Influence of the Therapeutic Dose of Atropine
Shih et al.
J. Pharmacol. Exp. Ther. 2007;320:154-161.
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Overcoming inhibitions
Kellar
Proc. Natl. Acad. Sci. USA 2006;103:13263-13264.
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The Pediatrician and Disaster Preparedness
Markenson et al.
Pediatrics 2006;117:e340-e362.
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Pathophysiological and clinical aspects of combat anticholinesterase poisoning
Weinbroum
Br Med Bull 2005;72:119-133.
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Nerve Agents: A Comprehensive Review
Wiener and Hoffman
J Intensive Care Med 2004;19:22-37.
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Anticholinergic and Antiglutamatergic Agents Protect against Soman-Induced Brain Damage and Cognitive Dysfunction
Raveh et al.
Toxicol Sci 2003;75:108-116.
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Neurological Aspects of Biological and Chemical Terrorism: A Review for Neurologists
Martin and Adams
Arch Neurol 2003;60:21-25.
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Management of Patients Exposed to Biological and Chemical Warfare Agents
Marik and Bowles
J Intensive Care Med 2002;17:147-161.
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The Role of the Clinical Laboratory in Managing Chemical or Biological Terrorism
Jortani et al.
Clin. Chem. 2000;46:1883-1893.
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Chemical-Biological Terrorism and Its Impact on Children: A Subject Review
Committee on Environmental Health and Committee on
Pediatrics 2000;105:662-670.
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