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Miriam J. Alter, PhD; Patrick J. Coleman, PhD; W. James Alexander, MD; Elizabeth Kramer, MSN; Joan K. Miller; Eric Mandel, MS; Stephen C. Hadler, MD; Harold S. Margolis, MD

JAMA. 1989;262(9):1201-1205.

Abstract
To identify previously unrecognized sources for acquiring acute hepatitis B and non-A, non-B (NANB) hepatitis, we interviewed patients with these types of hepatitis who were reported to two county health departments in the United States and matched control subjects for known and potential risk factors for acquiring hepatitis. Of 218 patients with hepatitis B and 140 patients with NANB hepatitis, 46% and 53%, respectively, had no commonly recognized source for infection. When these patients were compared with control subjects, significantly more patients with hepatitis B had multiple heterosexual partners, accounting for 14% of all hepatitis B infections; more patients with NANB hepatitis either had sexual or household contact with a person who had hepatitis in the past or had multiple heterosexual partners, accounting for 11% of all NANB infections. This is the first study to suggest that heterosexual transmission may play an important role in the spread of NANB hepatitis.

(JAMA. 1989;262:1201-1205)

Author Affiliations
From the Hepatitis Branch, Division of Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Ga (Drs Alter, Coleman, Hadler, and Margolis and Ms Miller and Mr Mandel); Jefferson County Department of Health, Birmingham, Ala (Dr Alexander); and Tacoma-Pierce County Health Department, Tacoma, Wash (Ms Kramer).

Footnotes
Reprint requests to Division of Viral Diseases, Centers for Disease Control, Hepatitis Branch, A-33, Bldg, Room 154, Atlanta, GA 30333 (Dr Alter).

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HETEROSEXUAL TRANSMISSION OF NON-A, NON-B HEPATITIS
JWatch General 1989;1989:1-1.
FULL TEXT