This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

A Time-Trend, Case-Control Study

Sidney J. Winawer, MD; Betty J. Flehinger, PhD; Joel Buchalter, MD; Elizabeth Herbert; Moshe Shike, MD

JAMA. 1990;263(15):2083-2085.

Abstract
We report the results of a 10-year, time-trend, case-control study in which serum cholesterol level was determined at several points in time preceding the diagnosis of colon cancer in a population of individuals who sought general checkups at an ambulatory care screening facility. Each of the 69 patients with colon cancer (32 men and 37 women) was matched with a control patient who was randomly selected. At the time of diagnosis, the patients with colon cancer had significantly lower serum cholesterol values than control patients (5.56 ± 0.31 mmol/L [SEM] vs 6.47 ±0.34 mmol/L). This difference did not vary with sex or Dukes' stage of the cancer. The percent of matched pairs in which the cancer patient had a lower serum cholesterol level increased from 42% at 10 years prior to cancer diagnosis to 77% at diagnosis. The ratio of serum cholesterol at each period to the level at time of diagnosis demonstrated an average decline of 13% during the 10 years prior to diagnosis for case patients vs an average rise of 2% in the same period for control patients. We conclude that individuals in whom colorectal cancer develops share the same level of serum cholesterol as the general population initially, but during the 10 years preceding the cancer demonstrate a decline in serum cholesterol level that is opposite to the rising level seen with age in the general population.

(JAMA. 1990;263:2083-2085)

Author Affiliations
From the Memorial Sloan-Kettering Cancer Center (Drs Winawer and Shike and Ms Herbert) and Preventive Medicine Institute—Strang Clinic (Dr Buchalter), New York, NY; and IBM T. J. Watson—Research Center, Yorktown Heights, NY (Dr Flehinger).

Footnotes
Reprint requests to Gastroenterology Service, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021 (Dr Winawer).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Statin Use and Risk of Colorectal Cancer
Coogan et al.
JNCI J Natl Cancer Inst 2007;99:32-40.
ABSTRACT | FULL TEXT  

The Munster Heart Study (PROCAM) : Total Mortality in Middle-Aged Men Is Increased at Low Total and LDL Cholesterol Concentrations in Smokers but Not in Nonsmokers
Cullen et al.
Circulation 1997;96:2128-2136.
ABSTRACT | FULL TEXT  

Meat Intake and Non-Hodgkin Lymphoma
Kritchevsky
JAMA 1996;276:524-524.
ABSTRACT  

Vitamin C and risk of death from stroke and coronary heart disease in cohort of elderly people
Gale et al.
BMJ 1995;310:1563-1566.
ABSTRACT | FULL TEXT  

Plasma Cholesterol Concentration and Mortality: The Whitehall Study
Smith et al.
JAMA 1992;267:70-76.
ABSTRACT  

Serum Cholesterol Level and Hepatoma
Chen et al.
JAMA 1990;264:2071-2072.
ABSTRACT