This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Harvey W. Kaufman, MD; Judith R. McNamara, MT; Keaven M. Anderson, PhD; Peter W. F. Wilson, MD; Ernst J. Schaefer, MD

JAMA. 1990;263(9):1245-1249.

Abstract
Five compact chemistry analyzers were evaluated for the measurement of lipids. Fresh plasma or serum specimens from a standardized research laboratory were assayed for total cholesterol on all five analyzers. Triglycerides and highdensity lipoprotein cholesterol were assayed on the three analyzers that could measure both of these analytes. Study results were interpreted by assessing accuracy and precision and by defining the percentage of patient specimens classified in the same categories as the reference laboratory, according to National Cholesterol Education Program guidelines. Two analyzers met standards for accuracy of cholesterol measurement. Three analyzers met performance standards for precision of cholesterol measurement. Agreement with National Cholesterol Education Program classification of specimens compared with the reference laboratory for total cholesterol ranged from 73% to 96% and was less for indirect low-density lipoprotein cholesterol. We conclude that under controlled conditions, compact chemistry analyzers vary in the reliability of lipid determination and classification of patients.

(JAMA. 1990;263:1245-1249)

Author Affiliations
From the Framingham (Mass) Union Hospital (Dr Kaufman); the Lipid Metabolism Laboratory, US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Mass (Dr Schaefer and Ms McNamara); and Framingham (Mass) Epidemiology Research Center, National Heart, Lung, and Blood Institute (Drs Anderson and Wilson). Dr Kaufman is now with the Department of Laboratory Medicine, The University Hospital, Boston, Mass.

Footnotes
Reprint requests to the Department of Laboratory Medicine, The University Hospital, 88 E Newton St, Boston, MA 02118 (Dr Kaufman).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Relation Between Leptin and the Metabolic Syndrome in Elderly Women
Zamboni et al.
Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2004;59:M396-M400.
ABSTRACT | FULL TEXT  

Lipoproteins, nutrition, and heart disease
Schaefer
Am. J. Clin. Nutr. 2002;75:191-212.
ABSTRACT | FULL TEXT  

Influence of Cholesterol Screening and Nutritional Counseling in Reducing Cholesterol Levels in Children
Fitch et al.
CLIN PEDIATR 1997;36:267-272.
ABSTRACT  

An Experimental Evaluation of an Incentive Program to Reduce Serum Cholesterol Levels Among Health Fair Participants
Francisco et al.
Arch Fam Med 1994;3:246-251.
ABSTRACT  

A Quality Assurance Program for the Measurement of Capillary Blood Cholesterol Levels in Private Pediatric Practices: The Children's Health Project
Bennett et al.
Arch Pediatr Adolesc Med 1993;147:340-345.
ABSTRACT  

Estimating an Individual's True Cholesterol Level and Response to Intervention
Irwig et al.
JAMA 1991;266:1678-1685.
ABSTRACT  

Lipoprotein Profiles in Hypercholesterolemic Children
Garcia and Moodie
Arch Pediatr Adolesc Med 1991;145:147-150.
ABSTRACT  

Portable Cholesterol Analyzers
Masse
JAMA 1990;264:1101-1101.
ABSTRACT  

Portable Cholesterol Analyzers
O'Neal
JAMA 1990;264:1101-1101.
ABSTRACT  

Portable Cholesterol Analyzers
Furst
JAMA 1990;264:1101-1101.
ABSTRACT  

PORTABLE CHOLESTEROL SCREENING IS OFTEN INACCURATE
JWatch General 1990;1990:1-1.
FULL TEXT  

Cardiac Risk Classification Based on Lipid Screening
Belsey and Baer
JAMA 1990;263:1250-1252.
ABSTRACT