How reliably can compact chemistry analyzers measure lipids?
H. W. Kaufman, J. R. McNamara, K. M. Anderson, P. W. Wilson and E. J. Schaefer
Framingham, Union Hospital, Boston, Mass.
Five compact chemistry analyzers were evaluated for the measurement of
lipids. Fresh plasma or serum specimens from a standardized research
laboratory were assayed for total cholesterol on all five analyzers.
Triglycerides and high-density lipoprotein cholesterol were assayed on the
three analyzers that could measure both of these analytes. Study results
were interpreted by assessing accuracy and precision and by defining the
percentage of patient specimens classified in the same categories as the
reference laboratory, according to National Cholesterol Education Program
guidelines. Two analyzers met standards for accuracy of cholesterol
measurement. Three analyzers met performance standards for precision of
cholesterol measurement. Agreement with National Cholesterol Education
Program classification of specimens compared with the reference laboratory
for total cholesterol ranged from 73% to 96% and was less for indirect
low-density lipoprotein cholesterol. We conclude that under controlled
conditions, compact chemistry analyzers vary in the reliability of lipid
determination and classification of patients.
