This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Ineffectiveness Against Chlamymydia trachomatis due to Relapsing Infection

Thomas M. Hooton, MD; M. Elizabeth Rogers, PA-C; Thomas G. Medina, PA-C; Lisa E. Kuwamura; Cynthia Ewers, PA; Pacita L. Roberts, MS; Walter E. Stamm, MD

JAMA. 1990;264(11):1418-1421.

Abstract
We compared 7-day regimens of ciprofloxacin in dosages of 750 and 1000 mg twice daily with doxycycline 100 mg twice daily for the treatment of nongonococcal urethritis in 178 men enrolled in a prospective, randomized, double-blind trial. The overall clinical response was comparable in the three treatment groups at both 2 and 4 weeks after therapy. However, among patients who initially had cultures positive for chlamydia, Chlamydia trachomatis was reisolated within 4 weeks after treatment in none of 10 doxycycline-treated patients, in 11 (52%) of 21 patients treated with 750 mg of ciprofloxacin twice daily, and in six (38%) of 16 patients treated with 1000 mg of ciprofloxacin twice daily. Each of the recurrent strains was identical in serotype to the original infecting strain. We conclude that ciprofloxacin in dosages as high as 2 g daily is inadequate for treatment of chlamydial urethritis in men, often resulting in relapsing infections.

(JAMA. 1990;264:1418-1421)

Author Affiliations
From the Department of Medicine, Harborview Medical Center, University of Washington School of Medicine, Seattle (Drs Hooton and Stamm and Mss Rogers, Kuwamura, Ewers, and Roberts); and the Tacoma-Pierce County Sexually Transmitted Disease Clinic, Tacoma, Wash (Mr Medina).

Footnotes
Reprint requests to Department of Medicine (ZA-60), Harborview Medical Center, 325 Ninth Ave, Seattle, WA 98104 (Dr Hooton).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The case for further treatment studies of uncomplicated genital Chlamydia trachomatis infection.
Horner
Sex. Transm. Infect. 2006;82:340-343.
ABSTRACT | FULL TEXT  

Persistence of Chlamydia trachomatis Is Induced by Ciprofloxacin and Ofloxacin In Vitro
Dreses-Werringloer et al.
Antimicrob. Agents Chemother. 2000;44:3288-3297.
ABSTRACT | FULL TEXT  

Long-term Eradication of Chlamydia trachomatis Genital Infection After Antimicrobial Therapy: Evidence Against Persistent Infection
Workowski et al.
JAMA 1993;270:2071-2075.
ABSTRACT  

Azithromycin in Chlamydial Urethritis
Workowski et al.
JAMA 1993;270:1934-1935.
ABSTRACT  

CIPROFLOXACIN IS INADEQUATE FOR CHLAMYDIAL URETHRITIS
JWatch General 1990;1990:4-4.
FULL TEXT