This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Jack E. Henningfield, PhD; Aleksandras Radzius; Thomas M. Cooper, DDS; Richard R. Clayton, PhD

JAMA. 1990;264(12):1560-1564.

Abstract
Patients failing to obtain benefit from nicotine polacrilex gum in their efforts to quit smoking may be inadvertently blocking nicotine absorption. Effective nicotine absorption depends on the mildly alkaline saliva that is produced when buffering agents in the polacrilex are released along with nicotine as the polacrilex is chewed. We found that intermittent mouth rinsing with coffee or cola, but not distilled water, substantially reduced salivary pH and nicotine absorption. Because many commonly consumed substances were also found to be highly acidic, we recommend that patients do not ingest any substance during or immediately before nicotine polacrilex use.

(JAMA. 1990;264:1560-1564)

Author Affiliations
From the Clinical Pharmacology Branch, National Institute on Drug Abuse, Addiction Research Center, Baltimore, Md (Dr Henningfield and Mr Radzius); Department of Community Dentistry, Albert B. Chandler Medical Center, Lexington, Ky (Dr Cooper); and Departments of Dentistry (Dr Cooper) and Sociology (Dr Clayton), University of Kentucky, Lexington.

Footnotes
Reprint requests to NIDA Addiction Research Center, PO Box 5180, Baltimore, MD 21224 (Dr Henningfield).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Smoking cessation pharmacotherapy
Frishman
Ther Adv Cardiovasc Dis 2009;3:287-308.
ABSTRACT  

Pharmacotherapy for Nicotine Dependence
Henningfield et al.
CA Cancer J Clin 2005;55:281-299.
ABSTRACT | FULL TEXT  

Pharmacokinetics and pharmacodynamics of moist snuff in humans
Fant et al.
Tobacco Control 1999;8:387-392.
ABSTRACT | FULL TEXT  

Nicotine Medications for Smoking Cessation
Henningfield
NEJM 1995;333:1196-1203.
FULL TEXT  

Effectiveness of the 4-mg Dose of Nicotine Polacrilex for the Initial Treatment of High-Dependent Smokers
Sachs
Arch Intern Med 1995;155:1973-1980.
ABSTRACT  

Cigarette Smoking, Nicotine Addiction, and Its Pharmacologic Treatment
Lee and D'Alonzo
Arch Intern Med 1993;153:34-48.
ABSTRACT  

Tobacco Dependence and the Nicotine Patch: Clinical Guidelines for Effective Use
Fiore et al.
JAMA 1992;268:2687-2694.
ABSTRACT