 |
|
Sexual Transmission Efficiency of Hepatitis B Virus and Human Immunodeficiency Virus Among Homosexual Men
Lawrence A. Kingsley, DrPH;
Charles R. Rinaldo, Jr, PhD;
David W. Lyter, MD;
Ronald O. Valdiserri, MD, MPH;
Steven H. Belle, PhD;
Monto Ho, MD
JAMA. 1990;264(2):230-234.
Abstract
| |
The relative sexual transmission efficiency of hepatitis B virus (HBV) and human immunodeficiency virus type 1 (HIV-1) was investigated by a prospective study of homosexual men in Pittsburgh, Pa, from the Multicenter AIDS Cohort Study. During the 30-month follow-up, 19.8% and 7.8% of the initially seronegative HBV and HIV-1 groups were estimated to seroconvert to HBV and HIV-1, respectively. The significantly higher cumulative HBV seroconversion rate occurred despite a much lower prevalence of hepatitis B carriers (7% were hepatitis B surface antigen positive) compared with HIV-1 carriers (22% were HIV-1 antibody positive). The sexual exposure profile of HBV and HIV-1 seroconverters was similar during the 6 months prior to seroconversion, supporting the link between anal intercourse and acquisition of either infection. However, insertive, not receptive, anal intercourse was the major risk factor identified for HBV seroconversion, suggesting that transurethral exposure is an important mode of transmission. These data suggest that HBV is transmitted 8.6-fold more efficiently than HIV-1 among homosexual men studied and underscore the benefits of both HBV immunization and use of condoms during intercourse to prevent HBV infection.
(JAMA. 1990;264:230-234)
Author Affiliations
From the Departments of Infectious Diseases and Microbiology (Drs Kingsley, Rinaldo, Valdiserri, and Ho) and Epidemiology (Drs Kingsley and Belle), Graduate School of Public Health, and the Departments of Pathology (Drs Rinaldo, Valdiserri, and Ho) and Medicine (Dr Lyter), School of Medicine, University of Pittsburgh (Pa).
Footnotes
Reprint requests to A417 Crabtree Hall, University of Pittsburgh, Pittsburgh, PA 15261 (Dr Kingsley).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Chronic Hepatitis B Infection: Principles of Therapy
Scarsi and Darin
Journal of Pharmacy Practice 2009;22:359-387.
ABSTRACT
Interaction between RANTES Promoter Variant and CCR5{Delta}32 Favors Recovery from Hepatitis B
Thio et al.
J. Immunol. 2008;181:7944-7947.
ABSTRACT
| FULL TEXT
A survey of hepatitis B and C prevalence amongst the homeless community of Prague
Volf et al.
Eur J Public Health 2008;18:44-47.
ABSTRACT
| FULL TEXT
Genetic Protection against Hepatitis B Virus Conferred by CCR5{Delta}32: Evidence that CCR5 Contributes to Viral Persistence
Thio et al.
J. Virol. 2007;81:441-445.
ABSTRACT
| FULL TEXT
Mannose Binding Lectin Genotypes Influence Recovery from Hepatitis B Virus Infection
Thio et al.
J. Virol. 2005;79:9192-9196.
ABSTRACT
| FULL TEXT
Cytotoxic T-Lymphocyte Antigen 4 Gene and Recovery from Hepatitis B Virus Infection
Thio et al.
J. Virol. 2004;78:11258-11262.
ABSTRACT
| FULL TEXT
Understanding correlates of hepatitis B virus vaccination in men who have sex with men: what have we learned?
Yee and Rhodes
Sex. Transm. Infect. 2002;78:374-377.
ABSTRACT
| FULL TEXT
The repertoire of human efforts to avoid sexually transmissible diseases: past and present. Part 2: Strategies used during or after sex
Donovan
Sex. Transm. Infect. 2000;76:88-93.
ABSTRACT
| FULL TEXT
The repertoire of human efforts to avoid sexually transmissible diseases: past and present Part 1: Strategies used before or instead of sex
Donovan
Sex. Transm. Infect. 2000;76:7-12.
ABSTRACT
| FULL TEXT
The Transmission Of HIV: Exploring Some Misconceptions Related to Criminal Justice
Blumberg
Criminal Justice Policy Review 1990;4:288-305.
ABSTRACT
HBV, HIV, and the Proscription of Intercourse
Harder
JAMA 1990;264:2625-2625.
ABSTRACT
|
