You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT JAMA
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 264 No. 23, December 19, 1990 TABLE OF CONTENTS
  JAMA
  •  Online Features
  ARTICLE
 This Article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in JAMA

Relationship of atherosclerosis in young men to serum lipoprotein cholesterol concentrations and smoking. A preliminary report from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group


Investigators in eight communities collected aortas, right coronary arteries, blood, and associated information from 390 males, 15 to 34 years of age, who died of violent causes. Pathologists at central laboratories graded the arteries for atherosclerotic lesions, and serum lipoprotein cholesterol and thiocyanate concentrations were measured. The percentage of intimal surface involved with atherosclerotic lesions in both the aorta and the right coronary artery was positively associated with serum very low-density lipoprotein + low-density lipoprotein cholesterol concentration and negatively associated with serum high-density lipoprotein cholesterol concentration. The serum thiocyanate concentration, a marker for smoking, was strongly associated with prevalence of raised lesions, particularly in the abdominal aorta. The effect of smoking was not explained by lipoprotein levels. Blacks had more extensive total surface involvement of the aorta after adjustment for lipoprotein cholesterol levels and smoking. These associations indicate that serum lipoprotein cholesterol concentrations and smoking are important determinants of the early stages of atherosclerosis in adolescents and young adults.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Preventing Heart Disease in the 21st Century: Implications of the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Study
McGill et al.
Circulation 2008;117:1216-1227.
FULL TEXT  

Differential Impact of Age, Sex, and Hypertension on Aortic Atherosclerosis: The Framingham Heart Study
Oyama et al.
Arterioscler. Thromb. Vasc. Bio. 2008;28:155-159.
ABSTRACT | FULL TEXT  

Summary of Workgroup Meeting on Use of Family History Information in Pediatric Primary Care and Public Health
Green
Pediatrics 2007;120:S87-S100.
ABSTRACT | FULL TEXT  

Diet and Primordial Prevention of Cardiovascular Disease in Children and Adolescents
Daniels
Circulation 2007;116:973-974.
FULL TEXT  

Statin Treatment in Children With Familial Hypercholesterolemia: The Younger, the Better
Rodenburg et al.
Circulation 2007;116:664-668.
ABSTRACT | FULL TEXT  

Screening and Treatment for Lipid Disorders in Children and Adolescents: Systematic Evidence Review for the US Preventive Services Task Force
Haney et al.
Pediatrics 2007;120:e189-e214.
ABSTRACT | FULL TEXT  

Drug Therapy of High-Risk Lipid Abnormalities in Children and Adolescents: A Scientific Statement From the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee, Council of Cardiovascular Disease in the Young, With the Council on Cardiovascular Nursing
McCrindle et al.
Circulation 2007;115:1948-1967.
ABSTRACT | FULL TEXT  

The Use of Statins in Pediatrics: Knowledge Base, Limitations, and Future Directions
Belay et al.
Pediatrics 2007;119:370-380.
ABSTRACT | FULL TEXT  

Cardiovascular Risk Reduction in High-Risk Pediatric Patients: A Scientific Statement From the American Heart Association Expert Panel on Population and Prevention Science; the Councils on Cardiovascular Disease in the Young, Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism, High Blood Pressure Research, Cardiovascular Nursing, and the Kidney in Heart Disease; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research: Endorsed by the American Academy of Pediatrics
Kavey et al.
Circulation 2006;114:2710-2738.
ABSTRACT | FULL TEXT  

Relationship Between Lipid Abnormalities and Insulin Resistance in Japanese School Children
Asato et al.
Arterioscler. Thromb. Vasc. Bio. 2006;26:2781-2786.
ABSTRACT | FULL TEXT  

Pathobiological Determinants of Atherosclerosis in Youth Risk Scores Are Associated With Early and Advanced Atherosclerosis
McMahan et al.
Pediatrics 2006;118:1447-1455.
ABSTRACT | FULL TEXT  

Utility of Childhood Non-High-Density Lipoprotein Cholesterol Levels in Predicting Adult Dyslipidemia and Other Cardiovascular Risks: The Bogalusa Heart Study
Srinivasan et al.
Pediatrics 2006;118:201-206.
ABSTRACT | FULL TEXT  

Dietary Recommendations for Children and Adolescents: A Guide for Practitioners
American Heart Association et al.
Pediatrics 2006;117:544-559.
ABSTRACT | FULL TEXT  

Dietary Recommendations for Children and Adolescents: A Guide for Practitioners: Consensus Statement From the American Heart Association
Endorsed by the American Academy of Pediatrics et al.
Circulation 2005;112:2061-2075.
ABSTRACT | FULL TEXT  

Lipid Profile of Children with a Family History of Coronary Heart Disease or Hyperlipidemia: 9-Year Experience of an Outpatient Clinic for the Prevention of Cardiovascular Diseases
Makedou et al.
ANGIOLOGY 2005;56:391-395.
ABSTRACT  

Surveillance and Treatment for CVD in Children With Diabetes
DOC News 2005;2:5-12.
FULL TEXT  

America's Children: A Critical Time for Prevention
Eckel et al.
Circulation 2005;111:1866-1868.
FULL TEXT  

Metabolic Syndrome Variables at Low Levels in Childhood Are Beneficially Associated With Adulthood Cardiovascular Risk: The Bogalusa Heart Study
Chen et al.
Diabetes Care 2005;28:126-131.
ABSTRACT | FULL TEXT  

Care of Children and Adolescents With Type 1 Diabetes: A statement of the American Diabetes Association
Silverstein et al.
Diabetes Care 2005;28:186-212.
FULL TEXT  

Cardiovascular Health Promotion in the Schools: A Statement for Health and Education Professionals and Child Health Advocates From the Committee on Atherosclerosis, Hypertension, and Obesity in Youth (AHOY) of the Council on Cardiovascular Disease in the Young, American Heart Association
Hayman et al.
Circulation 2004;110:2266-2275.
FULL TEXT  

Relationship Between Arterial Stiffness and Subclinical Aortic Atherosclerosis
Herrington et al.
Circulation 2004;110:432-437.
ABSTRACT | FULL TEXT  

Efficacy and Safety of Statin Therapy in Children With Familial Hypercholesterolemia: A Randomized Controlled Trial
Wiegman et al.
JAMA 2004;292:331-337.
ABSTRACT | FULL TEXT  

Genetic polymorphisms of apolipoprotein E4 and tumor necrosis factor {beta} as predisposing factors for increased inflammatory cytokines after cardiopulmonary bypass
Grunenfelder et al.
J. Thorac. Cardiovasc. Surg. 2004;128:92-97.
ABSTRACT | FULL TEXT  

Glucose-Cholesterol Interaction Magnifies Coronary Heart Disease Risk for Hypertensive Patients
Cohen et al.
Hypertension 2004;43:983-987.
ABSTRACT | FULL TEXT  

Patterns and Risk Factors for Systemic Calcified Atherosclerosis
Allison et al.
Arterioscler. Thromb. Vasc. Bio. 2004;24:331-336.
ABSTRACT | FULL TEXT  

Pediatric Precursors of Adult Atherosclerosis
Belay et al.
Pediatr. Rev. 2004;25:4-16.
FULL TEXT  

Cardiovascular Risk Factors in Childhood and Carotid Artery Intima-Media Thickness in Adulthood: The Cardiovascular Risk in Young Finns Study
Raitakari et al.
JAMA 2003;290:2277-2283.
ABSTRACT | FULL TEXT  

Effect of a High-Fat Ketogenic Diet on Plasma Levels of Lipids, Lipoproteins, and Apolipoproteins in Children
Kwiterovich et al.
JAMA 2003;290:912-920.
ABSTRACT | FULL TEXT  

Multi-Ethnic Study of Atherosclerosis: Objectives and Design
Bild et al.
Am J Epidemiol 2002;156:871-881.
ABSTRACT | FULL TEXT  

Distribution and Correlates of Non-High-Density Lipoprotein Cholesterol in Children: The Bogalusa Heart Study
Srinivasan et al.
Pediatrics 2002;110:e29-29.
ABSTRACT | FULL TEXT  

Dysmetabolic Syndrome: Multiple Risk Factors for Premature Adult Disease in an Adolescent Girl
Falkner et al.
Pediatrics 2002;110:e14-14.
ABSTRACT | FULL TEXT  

Age and Sex Distribution of Subclinical Aortic Atherosclerosis: A Magnetic Resonance Imaging Examination of the Framingham Heart Study
Jaffer et al.
Arterioscler. Thromb. Vasc. Bio. 2002;22:849-854.
ABSTRACT | FULL TEXT  

Coronary Calcium, Race, and Genes
Manolio and Bild
Arterioscler. Thromb. Vasc. Bio. 2002;22:359-360.
FULL TEXT  

Carotid Intimal-Medial Thickness Is Related to Cardiovascular Risk Factors Measured From Childhood Through Middle Age: The Muscatine Study
Davis et al.
Circulation 2001;104:2815-2819.
ABSTRACT | FULL TEXT  

Transcutaneous PO2 Response to Transient Arterial Occlusion In Peripheral Vascular Disease Detected by Heating Power Oximeter
Frau
ANGIOLOGY 2001;52:851-857.
ABSTRACT  

Myocardial Infarction in Young Adults With Low-Density Lipoprotein Cholesterol Levels <= 100 mg/dL : Clinical Profile and 1-Year Outcomes
Akosah et al.
Chest 2001;120:1953-1958.
ABSTRACT | FULL TEXT  

High Prevalence of Coronary Atherosclerosis in Asymptomatic Teenagers and Young Adults : Evidence From Intravascular Ultrasound
Tuzcu et al.
Circulation 2001;103:2705-2710.
ABSTRACT | FULL TEXT  

Noninvasive Assessment of the Early Progression of Atherosclerosis in Adolescents With Kawasaki Disease and Coronary Artery Lesions
Noto et al.
Pediatrics 2001;107:1095-1099.
ABSTRACT | FULL TEXT  

Cholesterol Guidelines Debate
Gidding; et al.
Pediatrics 2001;107:1229-1230.
FULL TEXT  

Long-Term Safety and Efficacy of a Cholesterol-Lowering Diet in Children With Elevated Low-Density Lipoprotein Cholesterol: Seven-Year Results of the Dietary Intervention Study in Children (DISC)
Obarzanek et al.
Pediatrics 2001;107:256-264.
ABSTRACT | FULL TEXT  

Origin of atherosclerosis in childhood and adolescence
McGill et al.
Am. J. Clin. Nutr. 2000;72 :1307S-1315S.
ABSTRACT | FULL TEXT  

Special Turku Coronary Risk Factor Intervention Project for Babies (STRIP)
Simell et al.
Am. J. Clin. Nutr. 2000;72 :1316S-1331S.
ABSTRACT | FULL TEXT  

Apolipoprotein epsilon 2 Allele Is Associated With an Anti-atherogenic Lipoprotein Profile in Children: The Columbia University BioMarkers Study
Isasi et al.
Pediatrics 2000;106:568-575.
ABSTRACT | FULL TEXT  

Cholesterol and Arterial Distensibility in the First Decade of Life : A Population-Based Study
Leeson et al.
Circulation 2000;101:1533-1538.
ABSTRACT | FULL TEXT  

Mild hypercholesterolemia and premature heart disease: do the national criteria underestimate disease risk?
Akosah et al.
J Am Coll Cardiol 2000;35:1178-1184.
ABSTRACT | FULL TEXT  

Leucine 7 to Proline 7 Polymorphism in the Preproneuropeptide Y Is Associated with Birth Weight and Serum Triglyceride Concentration in Preschool-Aged Children
Karvonen et al.
J. Clin. Endocrinol. Metab. 2000;85:1455-1460.
ABSTRACT | FULL TEXT  

A Comparison of the Framingham Risk Index, Coronary Artery Calcification, and Culprit Plaque Morphology in Sudden Cardiac Death
Taylor et al.
Circulation 2000;101:1243-1248.
ABSTRACT | FULL TEXT  

Family Dinner and Diet Quality Among Older Children and Adolescents
Gillman et al.
Arch Fam Med 2000;9:235-240.
ABSTRACT | FULL TEXT  

Lack of association of lipoprotein(a) levels with coronary calcium deposits in asymptomatic postmenopausal women
Nishino et al.
J Am Coll Cardiol 2000;35:314-320.
ABSTRACT | FULL TEXT  

The Role of Dietary Fat in Child Nutrition and Development: Summary of an ASNS Workshop
Milner and Allison
J. Nutr. 1999;129:2094-2105.
FULL TEXT  

Localization of Atherosclerosis: Role of Hemodynamics
Frangos et al.
Arch Surg 1999;134:1142-1149.
ABSTRACT | FULL TEXT  

Arterial remodeling in the left coronary system: The role of high-density lipoprotein cholesterol
Taylor et al.
J Am Coll Cardiol 1999;34:760-767.
ABSTRACT | FULL TEXT  

Increased Carotid Intimal-Medial Thickness and Coronary Calcification Are Related in Young and Middle-Aged Adults : The Muscatine Study
Davis et al.
Circulation 1999;100:838-842.
ABSTRACT | FULL TEXT  

Age-Dependent Association of Apolipoprotein E Genotype With Coronary and Aortic Atherosclerosis in Middle-Aged Men : An Autopsy Study
Ilveskoski et al.
Circulation 1999;100:608-613.
ABSTRACT | FULL TEXT  

Cholesterol Lowering in the Elderly Population
Grundy et al.
Arch Intern Med 1999;159:1670-1678.
ABSTRACT | FULL TEXT  

Childhood Passive Smoking, Race, and Coronary Artery Disease Risk: The MCV Twin Study
Moskowitz et al.
Arch Pediatr Adolesc Med 1999;153:446-453.
ABSTRACT | FULL TEXT  

Lipid and Apolipoprotein Predictors of Atherosclerosis in Youth : Apolipoprotein Concentrations Do Not Materially Improve Prediction of Arterial Lesions in PDAY Subjects
Rainwater et al.
Arterioscler. Thromb. Vasc. Bio. 1999;19:753-761.
ABSTRACT | FULL TEXT  

Prevalence and Extent of Atherosclerosis in Adolescents and Young Adults: Implications for Prevention From the Pathobiological Determinants of Atherosclerosis in Youth Study
Strong et al.
JAMA 1999;281:727-735.
ABSTRACT | FULL TEXT  

Usefulness of Electron Beam Tomography in Adolescents and Young Adults With Heterozygous Familial Hypercholesterolemia
Gidding et al.
Circulation 1998;98:2580-2583.
ABSTRACT | FULL TEXT  

Risk Factors and Progression of Atherosclerosis in Youth
Wissler and Strong
Am. J. Pathol. 1998;153:1023-1033.
FULL TEXT  

Association between Multiple Cardiovascular Risk Factors and Atherosclerosis in Children and Young Adults
Berenson et al.
NEJM 1998;338:1650-1656.
ABSTRACT | FULL TEXT  

When Should Heart Disease Prevention Begin?
Gaziano
NEJM 1998;338:1690-1692.
FULL TEXT  

Primary Prevention of Coronary Heart Disease: Guidance From Framingham : A Statement for Healthcare Professionals From the AHA Task Force on Risk Reduction
Grundy et al.
Circulation 1998;97:1876-1887.
FULL TEXT  

Hypertensive Vascular Disease as a Cause of Death in Blacks Versus Whites : Autopsy Findings in 587 Adults
Onwuanyi et al.
Hypertension 1998;31:1070-1076.
ABSTRACT | FULL TEXT  

Cardiovascular Disease Insulin Risk in Mexican-American and Anglo-American Children and Mothers
Reaven et al.
Pediatrics 1998;101 :e12-e12.
ABSTRACT | FULL TEXT  

Cholesterol in Childhood
Committee on Nutrition
Pediatrics 1998;101:141-147.
ABSTRACT | FULL TEXT  

Differences in HDL Cholesterol Concentrations in Japanese, American, and Australian Children
Dwyer et al.
Circulation 1997;96:2830-2836.
ABSTRACT | FULL TEXT  

Regulation of Growth of 7- to 36-Month-Old Children by Energy and Fat Intake in the Prospective, Randomized STRIP Baby Trial
Niinikoski et al.
Pediatrics 1997;100:810-816.
ABSTRACT | FULL TEXT  

Nutrition and Children : A Statement for Healthcare Professionals From the Nutrition Committee, American Heart Association
Fisher et al.
Circulation 1997;95:2332-2333.
FULL TEXT  

Influence of Cholesterol Screening and Nutritional Counseling in Reducing Cholesterol Levels in Children
Fitch et al.
CLIN PEDIATR 1997;36:267-272.
ABSTRACT  

Coronary Risk Factors and Plaque Morphology in Men with Coronary Disease Who Died Suddenly
Burke et al.
NEJM 1997;336:1276-1282.
ABSTRACT | FULL TEXT  

Parent and Physician Response to Children's Cholesterol Values of 200 mg/dL or Greater: The Child and Adolescent Trial for Cardiovascular Health Experiment
Nader et al.
Pediatrics 1997;99:e5-e5.
ABSTRACT | FULL TEXT  

Growth Until 3 Years of Age in a Prospective, Randomized Trial of a Diet With Reduced Saturated Fat and Cholesterol
Niinikoski et al.
Pediatrics 1997;99:687-694.
ABSTRACT | FULL TEXT  

Effects of Serum Lipoproteins and Smoking on Atherosclerosis in Young Men and Women
McGill et al.
Arterioscler. Thromb. Vasc. Bio. 1997;17:95-106.
ABSTRACT | FULL TEXT  

Hypercholesterolemia in the Rabbit Induced by Feeding Graded Amounts of Low-Level Cholesterol: Methodological Considerations Regarding Individual Variability in Response to Dietary Cholesterol and Development of Lesion Type
Kolodgie et al.
Arterioscler. Thromb. Vasc. Bio. 1996;16:1454-1464.
ABSTRACT | FULL TEXT  

Prospective Randomized Trial of Low-Saturated-Fat, Low-Cholesterol Diet During the First 3 Years of Life: The STRIP Baby Project
Niinikoski et al.
Circulation 1996;94:1386-1393.
ABSTRACT | FULL TEXT  

Risk Factors Related to Carotid Intima-Media Thickness and Plaque in Children With Familial Hypercholesterolemia and Control Subjects
Tonstad et al.
Arterioscler. Thromb. Vasc. Bio. 1996;16:984-991.
ABSTRACT | FULL TEXT  

Relation of a Postmortem Renal Index of Hypertension to Atherosclerosis in Youth
McGill et al.
Arterioscler. Thromb. Vasc. Bio. 1995;15:2222-2228.
ABSTRACT | FULL TEXT  

Low Atherosclerotic Response of a Strain of Rabbits to Diet-Induced Hypercholesterolemia
Thiery et al.
Arterioscler. Thromb. Vasc. Bio. 1995;15:1181-1188.
ABSTRACT | FULL TEXT  

Coronary Plaque Disruption
Falk et al.
Circulation 1995;92:657-671.
FULL TEXT  

Relation of Glycohemoglobin and Adiposity to Atherosclerosis in Youth
McGill et al.
Arterioscler. Thromb. Vasc. Bio. 1995;15:431-440.
ABSTRACT | FULL TEXT  

Serum Cholesterol in Young Men and Subsequent Cardiovascular Disease
Klag et al.
NEJM 1993;328:313-318.
ABSTRACT | FULL TEXT  

Pediatric Preventive Cardiology: Experience in the Tidewater, Virginia Area
Jennings and Leon
CLIN PEDIATR 1992;31:89-93.
ABSTRACT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1990 American Medical Association. All Rights Reserved.