Meta-Analysis of the Association of the Taq1A Polymorphism with the Risk of Alcohol Dependency: A HuGE Gene-Disease Association Review
Smith et al.
Am J Epidemiol 2008;167:125-138.
ABSTRACT
| FULL TEXT
ALCOHOLICS WITH THE DOPAMINE RECEPTOR DRD2 A1 ALLELE HAVE LOWER PLATELET MONOAMINE OXIDASE-B ACTIVITY THAN THOSE WITH THE A2 ALLELE: A PRELIMINARY STUDY
Eriksson et al.
Alcohol Alcohol 2000;35:493-498.
ABSTRACT
| FULL TEXT
Fatty acid ethyl esters: short-term and long-term serum markers of ethanol intake
Laposata
Clin. Chem. 1997;43:1527-1534.
ABSTRACT
| FULL TEXT
D2 Dopamine Receptor A1 Allele in Alzheimer Disease and Aging
Small et al.
Arch Neurol 1997;54:281-285.
ABSTRACT
A Man With Alcoholism and HIV Infection
Hyman
JAMA 1995;274:837-843.
ABSTRACT
D2 Dopamine Receptor Alleles Do Not Influence Severity of Tourette's Syndrome: Results From Four Large Kindreds
Gelernter et al.
Arch Neurol 1994;51:397-400.
ABSTRACT
No Structural Mutation in the Dopamine D2 Receptor Gene in Alcoholism or Schizophrenia: Analysis Using Denaturing Gradient Gel Electrophoresis
Gejman et al.
JAMA 1994;271:204-208.
ABSTRACT
The A1 Allele at the D2 Dopamine Receptor Gene and Alcoholism: A Reappraisal
Gelernter et al.
JAMA 1993;269:1673-1677.
ABSTRACT
Genetic Vulnerability to Drug Abuse: The D2 Dopamine Receptor Taq I B1 Restriction Fragment Length Polymorphism Appears More Frequently in Polysubstance Abusers
Smith et al.
Arch Gen Psychiatry 1992;49:723-727.
ABSTRACT
Addiction Medicine
Frances and Franklin
JAMA 1992;268:330-332.
ABSTRACT
Current Excitement With D2 Dopamine Receptor Gene Alleles in Substance Abuse
Uhl et al.
Arch Gen Psychiatry 1992;49:157-160.
ABSTRACT
The Dopamine D2 Receptor Locus as a Modifying Gene in Neuropsychiatric Disorders
Comings et al.
JAMA 1991;266:1793-1800.
ABSTRACT
NO Association Between an Allele at the D2 Dopamine Receptor Gene (DRD2) and Alcoholism
Gelernter et al.
JAMA 1991;266:1801-1807.
ABSTRACT
D2 Dopamine Receptor Gene Is Associated but Not Linked With Alcoholism
Cloninger
JAMA 1991;266:1833-1834.
ABSTRACT
PCR-SSCP: a simple and sensitive method for detection of mutations in the genomic DNA.
Hayashi
Genome Res 1991;1:34-38.
Association Between the D2 Dopamine Receptor Gene and Alcoholism: A Continuing Controversy
Conneally
Arch Gen Psychiatry 1991;48:757-759.
ABSTRACT
Allelic Association of the D2 Dopamine Receptor Gene With Receptor-Binding Characteristics in Alcoholism or Gene ism
Noble et al.
Arch Gen Psychiatry 1991;48:648-654.
ABSTRACT
Alcoholism and Alleles of the Human D2 Dopamine Receptor Locus: Studies of Association and Linkage
Parsian et al.
Arch Gen Psychiatry 1991;48:655-663.
ABSTRACT
Association Between the D2 Dopamine Receptor Gene and Alcoholism: A Continuing Controversy
Conneally
Arch Gen Psychiatry 1991;48:664-666.
ABSTRACT
Substance Abuse
Frances
JAMA 1991;265:3171-3172.
ABSTRACT
The Dopamine D2 Receptor Gene and Alcoholism
Noble and Blum
JAMA 1991;265:2667-2667.
ABSTRACT
The Dopamine D2 Receptor Gene and Alcoholism-Reply
Goldman et al.
JAMA 1991;265:2668-2668.
ABSTRACT
The Dopamine D2 Receptor Gene and Alcoholism
Smith et al.
JAMA 1991;265:2667-2668.
ABSTRACT
GENETIC MARKER FOR ALCOHOLISM QUESTIONED
JWatch General 1991;1991:5-5.
FULL TEXT
Quantitative trait loci and psychopharmacology
Plomin et al.
J Psychopharmacol 1991;5:1-9.
ABSTRACT
Identifying genes determining trait differences in behavior and drug response: a comment on 'Quantitative trait loci and psychopharmacology'
Goldman and Filling-Katz
J Psychopharmacol 1991;5:11-17.
ABSTRACT
hD2G1, Blum et al recently found that the D2/Taq I allele (A1) was present in 69% of 35 deceased alcoholics but in only 20% of an equal number of controls. To assess this association further, we evaluated the D2/Taq I polymorphism and a single-strand conformation polymorphism detected by polymerase chain reaction and nondenaturing gel electrophoresis (PCR-SSCP) of the 3' noncoding region of the D2 receptor gene. We studied 40 unrelated white alcoholics, 127 racially matched controls, and two white pedigrees. The Schedule for Affective Disorders and Schizophrenia—Lifetime Version (SADS-L) clinical diagnostic interviews were rated blindly by two clinicians. The SADS-L interviews and other data were then used to ascertain diagnoses according to the Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition (DSM-III-R) criteria. Alcoholics were subtyped according to age of onset, severity, presence of antisocial personality, and family history. No significant differences in either D2/Taq I or PCR-SSCP allele frequencies were observed between alcoholics, subpopulations of alcoholics, or controls. The PCR-SSCP polymorphism provided independent information against linkage at the D2 receptor locus. Several recombinants between the D2/Taq I locus and alcoholism were observed in two white families with an alcoholic parent who possessed the A1 allele. This study does not support a widespread or consistent association between the D2 receptor gene and alcoholism.