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Derivation and Validation of a Clinical Diagnostic Model for Chlamydial Cervical Infection in University Women
Betty A. Johnson, MD, PhD;
Roy M. Poses, MD;
Carolyn A. Fortner, MS;
Frederick A. Meier, MD;
Harry P. Dalton, PhD
JAMA. 1990;264(24):3161-3165.
Abstract
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We developed and prospectively tested a logistic regression model for chlamydial cervical infection. Study subjects included 2271 women receiving gynecologic care in our student health clinic. Clinical data were collected in a standardized fashion. We identified cell culture—isolated Chlamydia trachomatis from 133 (9%) of 1458 subjects in the derivation set and 73 (10%) of 729 subjects in the validation set. Model variables included a new sexual partner within 2 months or more than one sexual partner within 6 months; cervical ectopy; cervical friability; at least 20 polymorphonuclear leukocytes per high-power field in cervical secretions; white blood cells in vaginal secretions; and use of an antibiotic active against C trachomatis within a month. This model can distinguish women with low, medium, and high risks of chlamydial infection (on derivation set: receiver operating characteristic curve area, 0.710; SE, 0.026; on validation set: area, 0.698; SE, 0.035) using simple clinical information obtained in the office.
(JAMA. 1990;264:3161-3165)
Author Affiliations
From the Division of General Internal Medicine and Primary Care, Departments of Internal Medicine (Drs Johnson and Poses) and Biostatistics (Ms Fortner), and Clinical Microbiology Laboratory, Department of Pathology (Drs Meier and Dalton), Medical College of Virginia, Virginia Commonwealth University, Richmond.
Footnotes
Reprint requests to Box 102, MCV Station, Richmond, VA 23298 (Dr Johnson).
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