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A Placebo-Controlled, Double-Blind, Randomized Trial

Risto O. Roine, MD; Markku Kaste, MD; Ari Kinnunen, MD; Pertti Nikki, MD; Seppo Sarna, PhD; Soili Kajaste, MSc

JAMA. 1990;264(24):3171-3177.

Abstract
One hundred fifty-five consecutive patients resuscitated after out-of-hospital ventricular fibrillation by a physician-manned advanced life support unit were randomly assigned to receive nimodipine or placebo at a dosage of 10 µg/kg as an intravenous injection immediately after restoration of spontaneous circulation, followed by an infusion of 0.5 µg/kg per minute for 24 hours. No significant difference was found in the 1-year survival rate of nimodipine-treated (30 [40%] of 75 patients) and placebo-treated patients (29 [36%] of 80 patients). Recurrent ventricular fibrillation during the treatment occurred in one patient in the nimodipine group compared with 12 patients in the placebo group. In a post hoc analysis of patients with very long delays in advanced life support (more than 10 minutes), the 1-year survival rate was higher with nimodipine (eight [47%] of 17 patients) than with placebo (two [8%] of 26 patients). Nimodipine may be of benefit in patients with delayed resuscitation.

(JAMA. 1990;264:3171-3177)

Author Affiliations
From the Departments of Neurology (Drs Roine and Kaste and Mrs Kajaste), Anesthesiology (Dr Nikki), and Biometrics (Dr Sarna), University of Helsinki, and the Mobile Intensive Care Unit of Helsinki (Dr Kinnunen), Finland.

Footnotes
Reprint requests to Department of Neurology, University of Helsinki, SF-00290 Helsinki, Finland (Dr Roine).

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