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Successful Hyperlipemic Pregnancy
Susan L. Sanderson, MD;
Per-Henrik Iverius, MD, PhD;
Dana E. Wilson, MD
JAMA. 1991;265(14):1858-1860.
Abstract
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Women with hypertriglyceridemia are prone to gestational pancreatitis, a condition carrying substantial maternal and fetal risk. We describe a 33-year-old woman with familial hypertriglyceridemia who had recurrent hyperlipidemic abdominal crises during previous pregnancies despite dietary fat restrictions. A fifth pregnancy was carried to term without complications after aggressive dietary therapy and intermittent intravenous feeding, administered whenever her triglyceride levels exceeded an arbitrarily selected threshold concentration of 28 mmol/L. The efficacy of this approach may be explained by the published observation that low-fat (high-carbohydrate) isocaloric diets elevate serum triglyceride levels by the oral, but not the intravenous, route in normal individuals. Reduction of this patient's serum triglyceride concentrations by interrupting oral intake and administering intravenous glucose appeared to prevent late-pregnancy pancreatitis and culminated in uncomplicated full-term delivery.
(JAMA. 1991;265:1858-1860)
Author Affiliations
From the Veterans Affairs Medical Center, Salt Lake City, Utah; and the Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City.
Footnotes
Reprint requests to Endrocrinology Section, Veterans Affairs Medical Center, 500 Foothill Blvd, Salt Lake City, UT 84148 (Dr Sanderson).
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