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David V. Schapira, MBChB, FRCPC; Nagi B. Kumar, RD, MA; Gary H. Lyman, MD, MPH; Denis Cavanagh, MD; William S. Roberts, MD; James LaPolla, MD

JAMA. 1991;266(13):1808-1811.

Abstract
Study Objective.
—To determine if body fat distribution affected endometrial cancer risk.

Design.
—Case-control study.

Setting.
—This study was carried out at the H. Lee Moffitt Cancer Center at the University of South Florida, Tampa, where all patients in the case group received their diagnoses and histological confirmations.

Patients.
—Forty consecutive women newly diagnosed with endometrial cancer and 40 controls matched for age and Quetelet index.

Main Outcome Measures.
—Anthropometric measurements were taken for the abdomen, thigh, suprailiac, subscapular, biceps, and triceps skin fold thicknesses; waist and hip circumferences, weight, and height. Relative risks for endometrial cancer were calculated according to these anthropometric measurements.

Results.
—Case patients with endometrial cancer had significantly greater waist-to-hip circumference ratios (P<.001), abdomen-to-thigh skin fold ratios (P<.01), and suprailiac-to-thigh skin fold ratios (P =.02) compared with control subjects matched for age and Quetelet index. The relative risk for endometrial cancer increased with an increasing waist-to-hip circumference ratio (1.14 = 1.0; >1.14 = 15.0), with an increasing abdomen-to-thigh skin fold ratio (0.82= 1.0; >0.82 = 5.0), and with an increasing suprailiac to-thigh skin fold thickness ratio (0.67 = 1.0; >0.67 = 3.50).

Conclusion.
— Upper-body fat localization is a significant risk factor for endometrial cancer in women matched for age and Quetelet index.

(JAMA. 1991;266:1808-1811)

Author Affiliations
From the Section of Cancer Prevention, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa.

Footnotes
Reprint requests to H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr, Tampa, FL 33612 (Dr Schapira).

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