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Joseph R. Tobin, MD; Thomas P. Doyle, MD; Alice D. Ackerman, MD; Joel I. Brenner, MD

JAMA. 1991;266(19):2737-2740.

Abstract
The newly available antihistamine astemizole (Hismanal) has been previously associated with hemodynamically significant cardiac tachydysrhythmias. We describe a 3-year-old girl who developed multiple different cardiac dysrhythmias after an astemizole overdose. No hemodynamic compromise occurred, and the electrocardiogram returned to normal without use of antiarrhythmic agents within 7 hours.

(JAMA. 1991;266:2737-2740)

Author Affiliations
From the Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, Md (Dr Tobin), and the Department of Pediatrics (Drs Doyle, Ackerman, and Brenner), and the Divisions of Pediatric Critical Care Medicine (Dr Ackerman) and Pediatric Cardiology (Dr Brenner), The University of Maryland Medical System, Baltimore, Md.

Footnotes
Reprint requests to Johns Hopkins Hospital, Department of Anesthesiology and Critical Care Medicine, Blalock 1508, 600 N Wolfe St, Baltimore, MD 21205 (Dr Tobin).

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