Inverse association of dietary calcium with systolic blood pressure in young children
M. W. Gillman, S. A. Oliveria, L. L. Moore and R. C. Ellison
Evans Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, MA 02118.
OBJECTIVE--To investigate the association of dietary calcium with blood
pressure in young children. DESIGN--Cohort. SETTING--General community.
SUBJECTS--Eighty-nine boys and girls, aged 3 to 6 years, from The
Framingham Children's Study. MEASUREMENTS--During the first year of the
study, we derived nutrient data from multiple food diaries (a mean of 9.6
days of recording for each subject). At the beginning of the second year of
the study, we obtained anthropometric data and up to five blood pressure
readings (mean, 4.5) on each child at a single sitting. RESULTS--The range
of subjects' average daily calcium intake was 4.9 to 19.6 mmol per 4200 kJ,
with a mean of 12.8 mmol per 4200 kJ. Subjects' average systolic blood
pressure ranged from 73 to 129 mm Hg, with a mean of 95.9 mm Hg; for
diastolic blood pressure, the range was 37 to 78 mm Hg, mean 54.6 mm Hg.
Multiple linear regression analysis, adjusted for the effects of sex,
height, body mass index, and heart rate, showed that for each increment of
2.5 mmol of dietary calcium per 4200 kJ per day, systolic blood pressure
was 2.27 mm Hg lower (95% confidence interval, 0.63 to 3.91 mm Hg; P =
.008). We found no such association for diastolic blood pressure.
CONCLUSION--Dietary calcium is inversely related to systolic blood pressure
in young children.
