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Repeated Coronary Artery Spasm in a Young Woman With the Eosinophilia-Myalgia Syndrome
Phillip A. Hertzman, MD;
Gerry L. Maddoux, MD;
Esther M. Sternberg, MD;
Melvyn P. Heyes, PhD;
Ivan N. Mefford, PhD;
Gail M. Kephart;
Gerald J. Gleich, MD
JAMA. 1992;267(21):2932-2934.
Abstract
We report a case of repeated coronary artery spasm with myocardial injury in a 37-year-old woman with the eosinophilia-myalgia syndrome. This patient did not have a medical history of cardiac-related illness or risk factors for coronary artery disease. The presence of eosinophil granule major basic protein in otherwise normal-appearing myocardial tissue, along with normal plasma levels of tryptophan metabolites, suggests that the mechanism of vasospasm in this patient might involve toxic eosinophil proteins or focal myocardial lesions, but not the production of excess tryptophan metabolites.
(JAMA. 1992;267:2932-2934)
Author Affiliations
From the Los Alamos (NM) Medical Center, (Dr Hertzman), and The New Mexico Heart Clinic, Albuquerque (Dr Maddoux); the Alcohol, Drug Abuse, and Mental Health Administration, Bethesda, Md (Drs Sternberg, Heyes, and Mefford); and the Departments of Immunology and Medicine, Mayo Clinic, Rochester, Minn (Dr Gleich and Ms Kephart). Dr Hertzman has been retained as an expert by both plaintiffs and defendants in cases involving patients with the eosinophilia-myalgia syndrome. He had not been retained in any case involving the patient described in this article.
Footnotes
Reprint requests to Los Alamos Medical Center, Los Alamos, NM 87544 (Dr Hertzman).
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