You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT JAMA
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 267 No. 24, June 24, 1992 TABLE OF CONTENTS
  JAMA
  •  Online Features
  ARTICLE
 This Article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in JAMA

Risk of subsequent basal cell carcinoma and squamous cell carcinoma of the skin among patients with prior skin cancer. Skin Cancer Prevention Study Group

M. R. Karagas, T. A. Stukel, E. R. Greenberg, J. A. Baron, L. A. Mott and R. S. Stern
Department of Community and Family Medicine, Dartmouth Medical School, Hanover, NH 03755-3861.

OBJECTIVE--The primary aims of this study were to assess risk of subsequent basal and squamous cell skin cancer among patients with a prior history of these tumors and to examine these risks in relation to patient characteristics and life-style factors. DESIGN--Follow-up of participants in a randomized trial of betacarotene as a possible skin cancer preventive agent. SETTING--Clinical centers in Los Angeles, Calif, San Francisco, Calif, Minneapolis, Minn, and Hanover, NH. PARTICIPANTS--Patients (n = 1805) who were diagnosed as having a basal or squamous cell skin cancer between January 1980 and February 1986 and were free of skin cancer at study entry. MAIN OUTCOME MEASURE--Time from study entry to first new occurrence of basal and squamous cell skin cancer. RESULTS--The estimated risk of developing one or more new skin cancers was 35% at 3 years and 50% at 5 years. New skin cancers tended to be of the same cell type as the previous skin cancers. For both basal and squamous cell skin cancer, risk was higher among patients who were male, were over the age of 60 years, had more prior skin cancers, had severe actinic skin damage, or who burned easily with sun exposure. Compared with those who had never smoked, the rate of subsequent squamous cell skin cancer was higher among current smokers (rate ratio, 2.01; 95% confidence interval, 1.21 to 3.34) and former smokers (rate ratio, 1.62; 95% confidence interval, 1.07 to 2.47) and increased with both duration and amount smoked. There was no clear relationship between smoking and basal cell skin cancer; the rate appeared lower among heavy smokers but was unrelated to duration of smoking. CONCLUSIONS--Persons with a prior nonmelanoma skin cancer had a substantial 5-year risk of developing another tumor of the same histologic type. Number of previous skin cancers, solar damage, and skin sensitivity to sun exposure were particularly related to this risk. The increased risk of squamous cell skin cancer associated with cigarette smoking merits further study.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Nonmelanoma Skin Cancer and Risk for Subsequent Malignancy
Chen et al.
JNCI J Natl Cancer Inst 2008;100:1215-1222.
ABSTRACT | FULL TEXT  

Role of Dietary Factors in the Development of Basal Cell Cancer and Squamous Cell Cancer of the Skin
McNaughton et al.
Cancer Epidemiol. Biomarkers Prev. 2005;14:1596-1607.
ABSTRACT | FULL TEXT  

Repeated Occurrence of Basal Cell Carcinoma of the Skin and Multifailure Survival Analysis: Follow-up Data from the Nambour Skin Cancer Prevention Trial
Pandeya et al.
Am J Epidemiol 2005;161:748-754.
ABSTRACT | FULL TEXT  

Modulation of Patched-Associated Susceptibility to Radiation Induced Tumorigenesis by Genetic Background
Pazzaglia et al.
Cancer Res. 2004;64:3798-3806.
ABSTRACT | FULL TEXT  

Occurrence of Subclinical Tumor in Excised Facial Subunits
Lang et al.
Arch Facial Plast Surg 2004;6:158-161.
ABSTRACT | FULL TEXT  

Chemoprevention of Cancer
Tsao et al.
CA Cancer J Clin 2004;54:150-180.
ABSTRACT | FULL TEXT  

Risk of Basal Cell Carcinoma in Relation to Alcohol Intake and Smoking
Freedman et al.
Cancer Epidemiol. Biomarkers Prev. 2003;12:1540-1543.
ABSTRACT | FULL TEXT  

Keratinocyte Carcinoma
Albert and Weinstock
CA Cancer J Clin 2003;53:292-302.
ABSTRACT | FULL TEXT  

Skin Cancer Screening
Wills
ptjournal 2002;82:1232-1237.
ABSTRACT | FULL TEXT  

Intake of Alcohol and Alcoholic Beverages and the Risk of Basal Cell Carcinoma of the Skin
Fung et al.
Cancer Epidemiol. Biomarkers Prev. 2002;11:1119-1122.
ABSTRACT | FULL TEXT  

Patients Who Have Multiple Skin Cancers Develop New Skin Cancers at a Constant Rate
Czarnecki and Czarnecki
Arch Dermatol 2002;138:125-125.
FULL TEXT  

Modulation of Biologic Endpoints by Topical Difluoromethylornithine (DFMO), in Subjects at High-Risk for Nonmelanoma Skin Cancer
Einspahr et al.
Clin. Cancer Res. 2002;8:149-155.
ABSTRACT | FULL TEXT  

Basal Cell Carcinoma: Still an Enigma
Leman and McHenry
Arch Dermatol 2001;137:1239-1240.
FULL TEXT  

Relation Between Smoking and Skin Cancer
De Hertog et al.
JCO 2001;19:231-238.
ABSTRACT | FULL TEXT  

Risk of Developing a Subsequent Nonmelanoma Skin Cancer in Patients With a History of Nonmelanoma Skin Cancer: A Critical Review of the Literature and Meta-analysis
Marcil and Stern
Arch Dermatol 2000;136:1524-1530.
ABSTRACT | FULL TEXT  

Presentation with Multiple Cutaneous Basal Cell Carcinomas: Association of Glutathione S-Transferase and Cytochrome P450 Genotypes with Clinical Phenotype
Ramachandran et al.
Cancer Epidemiol. Biomarkers Prev. 1999;8:61-67.
ABSTRACT | FULL TEXT  

Intraepithelial and invasive squamous cell carcinoma of the conjunctiva: analysis of 60 cases
Tunc et al.
Br. J. Ophthalmol. 1999;83:98-103.
ABSTRACT | FULL TEXT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1992 American Medical Association. All Rights Reserved.