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A Placebo-Controlled, Double-blind, Randomized Trial

Michael R. England, MD; George Gordon, MD; Michael Salem, MD; Bart Chernow, MD

JAMA. 1992;268(17):2395-2402.

Abstract
Objective.
—To determine whether magnesium administration is effective in reducing postoperative morbidity and mortality after cardiac surgery.

Design.
—Randomized, double-blind, placebo-controlled trial.

Setting.
—A tertiary acute-care 500-bed university teaching hospital.

Patients.
—Over a 6-month period, 100 patients electively scheduled for cardiac surgery involving cardiopulmonary bypass were studied.

Interventions.
—Fifty patients were randomized to receive an intravenous infusion of magnesium chloride, 2 g, and 50 patients received placebo intraoperatively after the termination of cardiopulmonary bypass.

Results.
—Magnesium-treated patients had a significantly decreased frequency (P<.04) of postoperative ventricular dysrhythmias (eight [16%] of 50) compared with placebo-treated patients (17 [34%] of 50). Patients who were normomagnesemic postoperatively had new supraventricular dysrhythmias less frequently (P<.03) than patients who were hypomagnesemic postoperatively (eight [17%] of 48 vs 19 [37%] of 52). Compared with placebo-treated patients, magnesium-treated patients had significantly higher (P<.02) postoperative cardiac indices in the intensive care unit (2.8±0.1 vs 2.5±0.1 L/min per m²). Patients with postoperative total and ultrafilterable hypomagnesemia had postoperative ventricular dysrhythmias (P<.04) and required prolonged mechanical ventilatory support (P<.01) more frequently than patients without postoperative hypomagnesemia.

Conclusions.
—Total and ultrafilterable hypomagnesemia are prevalent findings in cardiac surgery patients, and postoperative hypomagnesemia is strongly associated with clinically important morbidity. Magnesium administration decreased the frequency of postoperative ventricular dysrhythmias and increased the stroke volume and thereby cardiac index in the early postoperative period.

(JAMA. 1992;268:2395-2402)

Author Affiliations
From the Division of Cardiac Anesthesia, Department of Anesthesia, New England Medical Center Hospital, Tufts University School of Medicine, Boston, Mass (Drs England and Gordon); and the Department of Medicine, Sinai Hospital of Baltimore, and the Departments of Medicine, Anesthesiology, and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Md (Drs Salem and Chernow).

Footnotes
Reprint requests to Physician-in-Chief, Sinai Hospital of Baltimore, Belvedere Avenue at Greenspring, Baltimore, MD 21215 (Dr Chernow).

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