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Jan Dequeker, MD, PhD, FRCP(Edin); Horacio Rico, MD, PhD

JAMA. 1992;268(2):249-251.

Abstract
Hand deformities resembling those of rheumatoid arthritis have been depicted in a painting by an anonymous artist of the Flemish-Dutch School, mid-15th to early 16th century. The painting is presently in the Escorial Museum near Madrid, Spain. This observation, like other earlier observations of rheumatoid deformities in paintings of the Middle Ages, suggests that rheumatoid arthritis is not a modern disease; it had, indeed, appeared several centuries before Landré-Beauvais' description in 1800.

(JAMA. 1992;268:249-251)

Author Affiliations
From the Arthritis and Metabolic Bone Disease Research Unit, K.U. Leuven, Belgium (Dr Dequeker), and the Sector Osteopatias, Hospital Universitario San Carlos, Madrid, Spain (Dr Rico). Dr Rico is now with the Departamento de Medicina, Universidad de Alcala de Henares, Madrid.

Footnotes
Reprint requests to Division of Rheumatology, U. Z. Pellenberg, B-3041 Pellenberg, Belgium (Dr Dequeker).

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