 |
|
Epidemiology of Invasive Childhood Pneumococcal Infections in Israel
Ron Dagan, MD;
Dan Englehard, MD;
Elie Piccard, MD;
the Israeli Pediatric Bacteremia and Meningitis Group;
Ron Dagan, MD;
Jacob Amir, MD;
Colin Block, MD;
Michael Dan, MD;
Moshe Drucker, MD;
Moshe Ephros, MD;
Dan Engelhard, MD;
Adir Faivisevitz, MSc;
Renalto Finkelstein, MD;
Zui Greif, MD;
Zion Houri, MD;
Meir Isaachson, MD;
Miriam Kaufstein, MSc;
Yehuda Karpuch, MD;
Ruth Lang, MD;
Amos Linden, MSc;
Dan Miron, MD;
Israel Potasman, MD;
Dora K. Segal, MD;
Itamar Shalit, MD;
Gila Shazberg, MD;
Atalla Shoukri, MD;
Menachem Schlezinger, MD;
Mordechaf Schreiber, MD
JAMA. 1992;268(23):3328-3332.
Abstract
| |
Objective.
—To study the epidemiology of childhood pneumococcal invasive infections in Israel as a background for immunization programs.
Design.
—A 2-year (October 1988 through September 1990) prospective, nationwide surveillance of all invasive pediatric pneumococcal infections.
Setting.
—All 25 medical centers hospitalizing children in Israel, including all laboratories performing blood cultures from pediatric patients.
Patients.
—Infants and children aged 0 to 12 years visiting the pediatric emergency department or hospitalized in pediatric departments were included if Streptococcus pneumoniae was isolated from blood or cerebrospinal fluid.
Results.
—Four hundred sixty-nine invasive infections were diagnosed. Pneumonia, bacteremia without apparent focus, meningitis, and cellulitis were found in 39%, 37%, 17%, and 3%, respectively. The annual incidence was 42 per 100000 for children younger than 5 years of age (104 per 100000 for those <12 months old). The two most common serotypes were 1 and 5, which are rare in Western Europe and North America. Eight groups comprised 82% of all invasive infections. Extrapolated to a population in which 100 000 live births occur yearly, the total annual hospitalizations for pneumococci infections was calculated to be 1928 days. The overall case-fatality rate was 2.2%, but it was 30% during the first month of life.
Conclusions.
—Pneumococcal invasive infections are common in children in Israel and carry considerable morbidity.
(JAMA. 1992;268:3328-3332)
Author Affiliations
| |
From the Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of Negev, Beer-Sheva, Israel (Dr Dagan), and Department of Pediatrics, Hadassah Medical Center, Jerusalem, Israel (Drs Englehard and Piccard).
Hasharon Medical Center, Petach Tikva; Sheba Medical Center, Tel Aviv; Wolfson Medical Center, Holon; Beilinson Medical Center, Petach Tikva; Carmel Medical Center, Haifa; Hadassah Medical Center, Jerusalem; Yoseftal Medical Center, Eilat; Rambam Medical Center, Haifa; Naharia Medical Center; Kaplan Medical Center, Rehovot; Shaarei-Zedek Medical Center, Jerusalem; Hillel Yaffe Medical Center, Hadera; Assaf Harofeh Medical Center, Zerifin; Meir Medical Center, Kfar-Saba; Poria Medical Center, Tveria; Haemek Medical Center, Afula; Bnei-Zion Medical Center, Haifa; Zfat Medical Center; Dana Children's Hospital, Tel Aviv; Bikur-Holim Medical Center, Jerusalem; Nazareth Medical Center; Barzilay Medical Center, Ashkelon; Laniado Medical Center, Netania
Footnotes
A complete list of the Israeli Pediatric Bacteremia and Meningitis Group appears at the end of this article.
Reprint requests to Pediatric Infectious Disease Unit, Soroka University Medical Center, PO Box 151, Beer-Sheva, Israel (Dr Dagan).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Trends in Bacteremia in the Pre- and Post-Highly Active Antiretroviral Therapy Era Among HIV-Infected Children in the US Perinatal AIDS Collaborative Transmission Study (1986-2004)
Kapogiannis et al.
Pediatrics 2008;121:e1229-e1239.
ABSTRACT
| FULL TEXT
Epidemiologic Features of Invasive Pneumococcal Disease in Belgian Children: Passive Surveillance Is Not Enough
Vergison et al.
Pediatrics 2006;118:e801-e809.
ABSTRACT
| FULL TEXT
Increase in numbers of {beta}-lactam-resistant invasive Streptococcus pneumoniae in Brazil and the impact of conjugate vaccine coverage.
Brandileone et al.
J Med Microbiol 2006;55:567-574.
ABSTRACT
| FULL TEXT
Antimicrobial susceptibility and serotype distribution of Streptococcus pneumoniae causing meningitis in Egypt, 1998-2003
Wasfy et al.
J Antimicrob Chemother 2005;55:958-964.
ABSTRACT
| FULL TEXT
Epidemiology of Invasive Streptococcus pneumoniae among Navajo Children in the Era before Use of Conjugate Pneumococcal Vaccines, 1989-1996
O'Brien et al.
Am J Epidemiol 2004;160:270-278.
ABSTRACT
| FULL TEXT
Twenty year surveillance of invasive pneumococcal disease in Nottingham: serogroups responsible and implications for immunisation
Ispahani et al.
Arch. Dis. Child. 2004;89:757-762.
ABSTRACT
| FULL TEXT
Antibiotic-Resistant Invasive Pediatric Streptococcus pneumoniae Clones in Israel
Greenberg et al.
J. Clin. Microbiol. 2003;41:5541-5545.
ABSTRACT
| FULL TEXT
Intranasal Immunization with Killed Unencapsulated Whole Cells Prevents Colonization and Invasive Disease by Capsulated Pneumococci
Malley et al.
Infect. Immun. 2001;69:4870-4873.
ABSTRACT
| FULL TEXT
Identification and Characterization of a Novel Family of Pneumococcal Proteins That Are Protective against Sepsis
Adamou et al.
Infect. Immun. 2001;69:949-958.
ABSTRACT
| FULL TEXT
Dissemination of a Chloramphenicol- and Tetracycline-Resistant but Penicillin-Susceptible Invasive Clone of Serotype 5 Streptococcus pneumoniae in Colombia
Tamayo et al.
J. Clin. Microbiol. 1999;37:2337-2342.
ABSTRACT
| FULL TEXT
Transplacental Transmission of Serotype-Specific Pneumococcal Antibodies in a Brazilian Population
Carvalho et al.
CVI 1999;6:50-54.
ABSTRACT
| FULL TEXT
Three-Year Multicenter Surveillance of Systemic Pneumococcal Infections in Children
Kaplan et al.
Pediatrics 1998;102:538-545.
ABSTRACT
| FULL TEXT
Capsular Serotype and Antibiotic Resistance of Streptococcus pneumoniae Isolates in Two Chilean Cities
Inostroza et al.
CVI 1998;5:176-180.
ABSTRACT
| FULL TEXT
Risk Factors for Primary Invasive Pneumococcal Disease Among Children in Finland
Takala et al.
JAMA 1995;273:859-864.
ABSTRACT
EPIDEMIOLOGY OF PNEUMOCOCCAL INFECTIONS IN CHILDREN
JWatch General 1992;1992:4-4.
FULL TEXT
New Challenges in the Development of a Conjugate Pneumococcal Vaccine
Baltimore
JAMA 1992;268:3366-3367.
ABSTRACT
|
