 |
|
Evolving Toward Effective Therapy for Acute Ischemic Stroke
Marc Fisher, MD;
Julien Bogousslavsky, MD
JAMA. 1993;270(3):360-364.
Abstract
| |
Acute ischemic stroke is a common, devastating disorder without beneficial therapy. Recent advances concerning the pathophysiology of ischemic brain injury have led to the development of rational pharmacological interventions. Thrombolytic and cytoprotective therapies may be useful and are being evaluated in clinical trials. The design of adequate clinical trials to evaluate these promising therapies has also evolved based on experience. Potential therapy for acute ischemic stroke must be assessed in a large number of patients who are given the intervention within hours of onset using a neurological scoring scale and a disability scale. Several new magnetic resonance imaging technologies are emerging that should allow the clinician to rapidly and accurately identify ischemic brain lesions and to evaluate cerebral perfusion. The availability of potentially efficacious therapies for ischemic stroke evaluated in well-designed clinical trials with magnetic resonance imaging technology, which can also assess therapeutic effects in vivo, should lead to the emergence of therapy to improve the outcome of patients with ischemic stroke in the near future.
(JAMA. 1993;270:360-364)
Author Affiliations
From the Department of Neurology, The Medical Center of Central Massachusetts and The University of Massachusetts Medical School, Worcester (Dr Fisher); and the Department of Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland (Dr Bogousslavsky).
Footnotes
Reprint requests to The Medical Center of Central Massachusetts, 119 Belmont St, Worcester, MA 01605 (Dr Fisher).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Recent progress in drug treatment for acute stroke
DEVUYST and BOGOUSSLAVSKY
J. Neurol. Neurosurg. Psychiatry 1999;67:420-425.
FULL TEXT
Effects of Citicoline Combined With Thrombolytic Therapy in a Rat Embolic Stroke Model • Editorial Comment
Andersen et al.
Stroke 1999;30:1464-1471.
ABSTRACT
| FULL TEXT
Ethical Challenges in Stroke Research
Slyter
Stroke 1998;29:1725-1729.
ABSTRACT
| FULL TEXT
Further Evolution Toward Effective Therapy for Acute Ischemic Stroke
Fisher and Bogousslavsky
JAMA 1998;279:1298-1303.
ABSTRACT
| FULL TEXT
Thrombolysis in acute stroke
Bogousslavsky
BMJ 1996;313:640-641.
FULL TEXT
Considerations in the Design of Clinical Trials of Neuroprotective Therapy in Acute Stroke
Dorman and Sandercock
Stroke 1996;27:1507-1515.
FULL TEXT
Undergraduate and Postgraduate Medical Education for Cerebrovascular Disease
Alberts
Stroke 1995;26:1849-1851.
ABSTRACT
| FULL TEXT
|
