This Article  • References  • Full text PDF  • Correction  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Jeremiah J. Levine, MD; Norman T. Ilowite, MD

JAMA. 1994;271(3):213-216.

Abstract
Objective.
—To determine whether breast-fed children of mothers with silicone implants are at increased risk for the development of sclerodermalike esophageal involvement compared with children not exposed to silicone implants.

Design.
—Case-control study.

Setting.
—Referral-based pediatric gastroenterology clinic.

Patients.
—Eleven children (mean age, 6.0 years; range, 1.5 to 13 years; six boys and five girls) referred for abdominal pain who were born to mothers who had silicone breast implants (eight breast-fed children and three bottle-fed) were compared with 17 patients (mean age, 10.7 years; range, 2 to 18 years; 11 boys and six girls) with abdominal pain who were not exposed to silicone implants.

Methods.
—All children underwent esophageal manometry and upper intestinal endoscopy with esophageal biopsy and were tested for antinuclear antibody and autoantibodies to Scl-70, centromere, ribonucleoprotein, Sm, Ro, La, and phospholipid.

Results.
—Six of the eight breast-fed children from mothers with silicone implants had significantly abnormal esophageal motility with nearly absent peristalsis in the distal two thirds of the esophagus and decreased lower sphincter pressure. Upper esophageal pressures and motility were normal. Compared with controls, the breast-fed children had significantly decreased lower sphincter pressure and abnormal esophageal wave propagation. These manometric abnormalities were not seen in the three bottle-fed children. There was no difference in the expression of autoantibodies in the breast-fed children compared with the bottle-fed children or controls.

Conclusions.
—A relationship appears to exist between breast-feeding by mothers with silicone implants and abnormal esophageal motility. Studies evaluating larger numbers of children are needed to determine the extent of the risk.

(JAMA. 1994;271:213-216)

Author Affiliations
From the Divisions of Pediatric Gastroenterology and Nutrition (Dr Levine) and Rheumatology (Dr Ilowite), Schneider Children's Hospital, Long Island Jewish Medical Center, Long Island Campus of the Albert Einstein College of Medicine, New Hyde Park, NY.

Footnotes
Reprint requests to Pediatric Gastroenterology and Nutrition, Schneider Children's Hospital, Room 229, Albert Einstein College of Medicine, New Hyde Park, NY 11042 (Dr Levine).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Breastfeeding After Breast Augmentation
Hurst
J Hum Lact 2003;19:70-71.
 

The Transfer of Drugs and Other Chemicals Into Human Milk
Committee on Drugs
Pediatrics 2001;108:776-789.
ABSTRACT | FULL TEXT  

Health Outcomes in Offspring of Mothers With Breast Implants
Kjøller et al.
Pediatrics 1998;102:1112-1115.
ABSTRACT | FULL TEXT  

Media are too eager to link silicone to disease
Collis et al.
BMJ 1998;316:477-477.
FULL TEXT  

Should Breast-feeding by Women With Silicone Implants Be Recommended?
Jordan and Blum
Arch Pediatr Adolesc Med 1996;150:880-881.
ABSTRACT  

Silicone Breast Implants and Sclerodermalike Esophageal Disease in Breast-fed Infants
Epstein
JAMA 1996;275:184-184.
ABSTRACT  

Silicone Breast Implants and Sclerodermalike Esophageal Disease in Breast-fed Infants-Reply
Levine and Ilowite
JAMA 1996;275:184-185.
ABSTRACT  

Sonoographic Detection of Silicone Breast Implant Rupture
Lu et al.
Journal of Diagnostic Medical Sonography 1995;11:3-8.
ABSTRACT  

New Environmental Agents Associated With Lupus-Like Disorders
Love
Lupus 1994;3:467-471.
ABSTRACT  

Sclerodermalike Esophageal Disease in Children of Mothers With Silicone Breast Implants
Epstein
JAMA 1994;272:768-768.
ABSTRACT  

Sclerodermalike Esophageal Disease in Children of Mothers With Silicone Breast Implants
Liau et al.
JAMA 1994;272:769-769.
ABSTRACT  

Sclerodermalike Esophageal Disease in Children of Mothers With Silicone Breast Implants
Bartel
JAMA 1994;272:767-767.
ABSTRACT  

Sclerodermalike Esophageal Disease in Children of Mothers With Silicone Breast Implants
Cook
JAMA 1994;272:767-768.
ABSTRACT  

Sclerodermalike Esophageal Disease in Children of Mothers With Silicone Breast Implants
Placik
JAMA 1994;272:768-769.
ABSTRACT  

Sclerodermalike Esophageal Disease in Children of Mothers With Silicone Breast Implants
Levine
JAMA 1994;272:769-769.
ABSTRACT  

Sclerodermalike Esophageal Disease in Children of Mothers With Silicone Breast Implants-Reply
Levine and Ilowite
JAMA 1994;272:769-770.
ABSTRACT  

Sclerodermalike Esophageal Disease in Children of Mothers With Silicone Breast Implants-Reply
Flick
JAMA 1994;272:770-770.
ABSTRACT  

Scleroderma-like Disease in Breast-fed Children of Mothers with Silicone Implants
Journal Watch Dermatology 1994;1994:4-4.
FULL TEXT  

CAN SILICONE IMPLANTS HARM BREAST-FED CHILDREN?
JWatch General 1994;1994:3-3.
FULL TEXT  

Silicone Implants and Esophageal Dysmotility: Are Breast-fed Infants at Risk?
Flick
JAMA 1994;271:240-241.
ABSTRACT