This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Michael Miller, MD; Grover M. Hutchins, MD

JAMA. 1994;272(3):231-233.

Abstract
Objective.
—To examine the prevalence of coronary artery disease (CAD) in autopsies of patients with iron-overload syndromes.

Design.
—Retrospective autopsy study of CAD in cases of hemochromatosis and multiorgan hemosiderosis.

Setting.
—Registry of nearly 48000 autopsies performed at The Johns Hopkins Hospital between 1889 and 1992.

Subjects.
—One hundred twenty-three subjects were studied. In a 2:1 control-case ratio, 82 controls matched by age, race, and sex were compared with 41 cases with iron overload.

Main Outcome Measure.
—Severity of CAD.

Results.
—Pathological description of the coronary arteries were recorded as advanced or severe in 12% of iron-overload cases(n=41) (mean age, 57.6±13.2 years) compared with 38% of controls (n=82) (mean age, 57.0±13.8 years) (P=.01). The prevalence of three-vessel disease assessed by postmortem coronary arteriography was 11.1% in iron-overload cases (n=18) (mean age, 61.7±12.2 years) compared with 33.3% in controls (n=36) (mean age, 61.1±12.5 years) (P=.04). The odds ratio of CAD with iron overload was 0.18 (95% confidence interval, 0.04 to 0.73).

Conclusions.
—Iron overload resulting from hemochromatosis or multiorgan hemosiderosis is not associated with an increased prevalence of CAD.

(JAMA. 1994;272:231-233)

Author Affiliations
From the Division of Cardiology, University of Maryland Medical System (Dr Miller), and the Autopsy Pathology Division of the Department of Pathology, The Johns Hopkins Medical Institutions (Dr Hutchins), Baltimore, Md.

Footnotes
Reprint requests to Division of Cardiology-N3W80, University of Maryland Hospital, 22 S Greene St, Baltimore, MD 21201 (Dr Miller).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Macrophage Iron, Hepcidin, and Atherosclerotic Plaque Stability
Sullivan
Exp. Biol. Med. 2007;232:1014-1020.
ABSTRACT | FULL TEXT  

Role of Oxidative Modifications in Atherosclerosis
Stocker and Keaney
Physiol. Rev. 2004;84:1381-1478.
ABSTRACT | FULL TEXT  

Impairment of Transendothelial Leukocyte Migration by Iron Complexes
Sengoelge et al.
J. Am. Soc. Nephrol. 2003;14:2639-2644.
ABSTRACT | FULL TEXT  

Haemochromatosis (HFE) gene C282Y mutation and the risk of coronary artery disease and myocardial infarction: a study in 1279 patients undergoing coronary angiography
Surber et al.
J. Med. Genet. 2003;40:e58-58.
FULL TEXT  

Iron Overload in Hypercholesterolemic Rats Affects Iron Homeostasis and Serum Lipids but Not Blood Pressure
Turbino-Ribeiro et al.
J. Nutr. 2003;133:15-20.
ABSTRACT | FULL TEXT  

Mutations in the Hemochromatosis Gene (HFE) and Stroke
Njajou et al.
Stroke 2002;33:2363-2366.
ABSTRACT | FULL TEXT  

Do body iron stores increase the risk of developing coronary heart disease?
Sempos
Am. J. Clin. Nutr. 2002;76:501-503.
FULL TEXT  

Blood Donations and Risk of Coronary Heart Disease in Men
Ascherio et al.
Circulation 2001;103:52-57.
ABSTRACT | FULL TEXT  

Iron and the Genetics of Cardiovascular Disease
Sullivan
Circulation 1999;100:1260-1263.
FULL TEXT  

Mass spectrometric quantification of amino acid oxidation products in proteins: insights into pathways that promote LDL oxidation in the human artery wall
HEINECKE
FASEB J. 1999;13:1113-1120.
ABSTRACT | FULL TEXT  

Public Health Surveillance for Hereditary Hemochromatosis
Wetterhall et al.
ANN INTERN MED 1998;129:980-986.
ABSTRACT | FULL TEXT  

Effect of Iron Overload and Iron Deficiency on Atherosclerosis in the Hypercholesterolemic Rabbit
Dabbagh et al.
Arterioscler. Thromb. Vasc. Bio. 1997;17:2638-2645.
ABSTRACT | FULL TEXT  

Oxidation-Related Analytes and Lipid and Lipoprotein Concentrations in Healthy Subjects
Craig et al.
Arterioscler. Thromb. Vasc. Bio. 1995;15:733-739.
ABSTRACT | FULL TEXT  

Hemochromatosis and Coronary Artery Disease
Sullivan
JAMA 1995;273:25-26.
ABSTRACT