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Suitability of Fetal Tissues From Spontaneous Abortions and From Ectopic Pregnancies for Transplantation
D. Ware Branch, MD;
Lee Ducat;
Alan Fantel, PhD;
Walter C. Low, PhD;
Feng C. Zhou, PhD;
Delbert H. Dayton, MD;
Thomas J. Gill III, MD;
The Human Fetal Tissue Working Group;
Sharon Bledsoe;
Yung-Hsiao Chiang, MD;
Sonny K. Chong, MD;
Bryan E. Hainline, MD;
Stephen A. Heifetz, MD;
Debra Kahlenbeck;
Qinyuan Low, MD;
Lillie-Mae Padilla, MD;
Catherine Palmer, PhD;
Daniel Peavy, PhD;
Bruce Blazer, MD;
Jeff Blount, MD;
Judy Christianson, RN, BSN;
Gayl Chrysler, BAN, MBA;
John Conrad;
Laura Coultrip, MD;
Peter D'Ascoli, MD;
Ted Eastlund, MD;
Jeanne Forbes, MSW;
Tom Gasser;
Mark Hirschel, PhD;
Warren Kearney, MPH;
Takeshi Kondoh, MD;
Ying-jie Li, MD;
Sandy Maynard, RN;
Jeff Miller, MD;
Beverly Norris;
Takashi Okagaki, MD, PhD, MPH;
Anne Peterson, MPH;
Lisa Pundt, MS;
Ranjita Sengupta;
Catherine Verfaillie, MD;
Beth Virnig, PhD;
Kathy Weese, BSN, RN;
Preston Williams, MD;
Kelly Feil;
Alberto Hayek, MD;
Virginia Lee, PhD;
Michael K. McCormack, PhD;
F. Arthur McMorris, PhD;
Susan Shen-Schwarz, MD;
John Q. Trojanowski, MD, PhD;
Janice L. B. Byrne, MD;
Kenneth Ward, MD;
Sharon Hillier, PhD;
Molly Hogan;
Raj Kapur, MD;
Marijane Krohn, PhD;
Kathy Leppig, MD;
Julie Mason;
Beth Mueller, DrPH;
Helen Newman-Gage, PhD;
Thomas Norwood, MD;
Ted Rigley;
Soe Soe Thwin;
Tara Vick
JAMA. 1995;273(1):66-68.
Abstract
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Objective.
—To assess the potential availability and utility of fetal tissues obtained from spontaneous abortions and from ectopic pregnancies for human transplantation therapy.
Design.
—Tissue collection and analysis by personnel skilled in tissue banking.
Setting.
—Procurement programs in five tissue banks located in diverse geographical areas that are funded by the National Institutes of Health.
Patients.
—All women entering obstetric clinics during 1993 who consented to participate in the study.
Interventions.
—None.
Main Outcome Measures.
—Evaluation of the products of conception by standard developmental, histological, microbiological, and cytogenetic criteria.
Results.
—From 22235 obstetric admissions, 1250 spontaneously aborted embryos and 247 products of ectopic pregnancies were obtained. Of these, seven embryos (0.5%) were potentially useful for human transplantation therapy.
Conclusion.
—Fetal tissues from spontaneous abortions and from ectopic pregnancies are quite limited as feasible sources for human transplantation therapy.
(JAMA. 1995;273:66-68)
Author Affiliations
Indiana University, Indianapolis; University of Minnesota, Minneapolis; National Disease Research Interchange, Philadelphia, Pa; University of Utah, Salt Lake City; University of Washington, Seattle
From the Department of Obstetrics and Gynecology, University of Utah, Salt Lake City (Dr Branch); National Disease Research Interchange, Philadelphia, Pa (Ms Ducat); Department of Pediatrics, University of Washington, Seattle (Dr Fantel); Department of Neurosurgery, University of Minnesota, Minneapolis (Dr Low); Department of Anatomy, Indiana University, Indianapolis (Dr Zhou); Genetics and Teratology Branch, National Institute of Child Health and Human Development, Bethesda, Md (Dr Dayton); and Department of Pathology, University of Pittsburgh (Pa) (Dr Gill).
Footnotes
A complete list of the members of The Human Fetal Tissue Working Group appears at the end of this article.
Reprint requests to Department of Pathology, University of Pittsburgh School of Medicine, 3550 Terrace St, S-705 Scaife Hall, Pittsburgh, PA 15261 (Dr Gill).
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ABSTRACT
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