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Liesi E. Hebert, ScD; Paul A. Scherr, PhD, ScD; Laurel A. Beckett, PhD; Marilyn S. Albert, PhD; David M. Pilgrim, MD; Marilyn J. Chown, MPH; H. Harris Funkenstein, MD; Denis A. Evans, MD

JAMA. 1995;273(17):1354-1359.

Abstract
Objective.
—To determine age-specific incidence rates of clinically diagnosed Alzheimer's disease.

Design.
—Cohort, followed a mean of 4.3 years.

Setting.
—East Boston, Mass.

Participants.
—Of 2313 persons aged 65 years and older who were initially free of Alzheimer's disease, 1601 participated in the ascertainment of incident disease (80% of survivors), 409 declined participation, and 303 died before the end of the follow-up period. A stratified sample of 642 persons received detailed clinical evaluation.

Outcome Measure.
—Diagnosis of new probable Alzheimer's disease through structured clinical evaluation including neurologic, neuropsychological, and psychiatric examination. Community incidence rates were computed by 5-year age groups, adjusted for gender, single year of age, length of follow-up interval, and sampling design.

Results.
—The estimated annual incidence of Alzheimer's disease in the population was 0.6% (95% confidence interval [Cl], 0.3% to 0.9%) for persons aged 65 to 69 years, 1.0% (95% Cl, 0.6% to 1.4%) for persons aged 70 to 74 years, 2.0% (95% Cl, 1.3% to 2.7%) for persons aged 75 to 79 years, 3.3% (95% Cl, 2.2% to 4.4%) for persons aged 80 to 84 years, and 8.4% (95% Cl, 3.7% to 13.1%) for persons aged 85 years and older.

Conclusions.
—The incidence of Alzheimer's disease is substantial and is approximately 14 times higher among persons older than 85 years compared with those between 65 and 69 years of age.

(JAMA. 1995;273:1354-1359)

Author Affiliations
From the Rush Institute on Aging and Rush Alzheimer's Disease Center, Rush University and Rush-Presbyterian-St Luke's Medical Center, Chicago, III (Drs Hebert, Beckett, and Evans); Aging Studies Branch, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Ga (Dr Scherr); Departments of Psychiatry and Neurology, Massachusetts General Hospital, and Department of Psychiatry, Harvard Medical School (Dr Albert), Harvard Community Health Plan (Dr Pilgrim), Harvard School of Public Health (Ms Chown), Division of Neurology, Brigham and Women's Hospital, and Department of Neurology, Harvard Medical School (Dr Funkenstein), Boston, Mass.

Footnotes
Deceased.

Presented in part at the annual meeting of the Society for Epidemiologic Research, Buffalo, NY, June 12, 1991.

Reprint requests to Rush Institute on Aging, 1645 W Jackson Blvd, Suite 675, Chicago, IL 60612 (Dr Hebert).

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