This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Liesi E. Hebert, ScD; Paul A. Scherr, PhD, ScD; Laurel A. Beckett, PhD; Marilyn S. Albert, PhD; David M. Pilgrim, MD; Marilyn J. Chown, MPH; H. Harris Funkenstein, MD; Denis A. Evans, MD

JAMA. 1995;273(17):1354-1359.

Abstract
Objective.
—To determine age-specific incidence rates of clinically diagnosed Alzheimer's disease.

Design.
—Cohort, followed a mean of 4.3 years.

Setting.
—East Boston, Mass.

Participants.
—Of 2313 persons aged 65 years and older who were initially free of Alzheimer's disease, 1601 participated in the ascertainment of incident disease (80% of survivors), 409 declined participation, and 303 died before the end of the follow-up period. A stratified sample of 642 persons received detailed clinical evaluation.

Outcome Measure.
—Diagnosis of new probable Alzheimer's disease through structured clinical evaluation including neurologic, neuropsychological, and psychiatric examination. Community incidence rates were computed by 5-year age groups, adjusted for gender, single year of age, length of follow-up interval, and sampling design.

Results.
—The estimated annual incidence of Alzheimer's disease in the population was 0.6% (95% confidence interval [Cl], 0.3% to 0.9%) for persons aged 65 to 69 years, 1.0% (95% Cl, 0.6% to 1.4%) for persons aged 70 to 74 years, 2.0% (95% Cl, 1.3% to 2.7%) for persons aged 75 to 79 years, 3.3% (95% Cl, 2.2% to 4.4%) for persons aged 80 to 84 years, and 8.4% (95% Cl, 3.7% to 13.1%) for persons aged 85 years and older.

Conclusions.
—The incidence of Alzheimer's disease is substantial and is approximately 14 times higher among persons older than 85 years compared with those between 65 and 69 years of age.

(JAMA. 1995;273:1354-1359)

Author Affiliations
From the Rush Institute on Aging and Rush Alzheimer's Disease Center, Rush University and Rush-Presbyterian-St Luke's Medical Center, Chicago, III (Drs Hebert, Beckett, and Evans); Aging Studies Branch, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Ga (Dr Scherr); Departments of Psychiatry and Neurology, Massachusetts General Hospital, and Department of Psychiatry, Harvard Medical School (Dr Albert), Harvard Community Health Plan (Dr Pilgrim), Harvard School of Public Health (Ms Chown), Division of Neurology, Brigham and Women's Hospital, and Department of Neurology, Harvard Medical School (Dr Funkenstein), Boston, Mass.

Footnotes
Deceased.

Presented in part at the annual meeting of the Society for Epidemiologic Research, Buffalo, NY, June 12, 1991.

Reprint requests to Rush Institute on Aging, 1645 W Jackson Blvd, Suite 675, Chicago, IL 60612 (Dr Hebert).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The Vote of Acute Medical Inpatients: A Prospective Study
Bosquet et al.
J Aging Health 2009;21:699-712.
ABSTRACT  

Influence of Cognitive Status, Age, and APOE-4 Genetic Risk on Brain FDDNP Positron-Emission Tomography Imaging in Persons Without Dementia
Small et al.
Arch Gen Psychiatry 2009;66:81-87.
ABSTRACT | FULL TEXT  

Role of the Neuropathology of Alzheimer Disease in Dementia in the Oldest-Old
Haroutunian et al.
Arch Neurol 2008;65:1211-1217.
ABSTRACT | FULL TEXT  

The Prevalence of Dementia in an Urban Turkish Population
Gurvit et al.
AM J ALZHEIMERS DIS OTHER DEMEN 2008;23:67-76.
ABSTRACT  

Cheap solutions for big problems?
McCrory
Br. J. Sports. Med. 2007;41:545-545.
FULL TEXT  

How common are the "common" neurologic disorders?
Hirtz et al.
Neurology 2007;68:326-337.
ABSTRACT | FULL TEXT  

Aging of the brain, entropy, and Alzheimer disease
Drachman
Neurology 2006;67:1340-1352.
ABSTRACT | FULL TEXT  

Benchmarks for designing two-stage studies using modified mini-mental state examinations: experience from the Women's Health Initiative Memory Study
Espeland et al.
Clin Trials 2006;3:99-106.
ABSTRACT  

The different paths to 100
Perls
Am. J. Clin. Nutr. 2006;83:484S-487S.
ABSTRACT | FULL TEXT  

Children of Alzheimer Patients: An Overview
Jarvik and Blazer
J Geriatr Psychiatry Neurol 2005;18:181-186.
 

Cholinesterase Inhibitors in the Treatment of Dementia
Ellis
JAOA: Journal of the American Osteopathic Association 2005;105:145-158.
ABSTRACT | FULL TEXT  

Dietary niacin and the risk of incident Alzheimer's disease and of cognitive decline
Morris et al.
J. Neurol. Neurosurg. Psychiatry 2004;75:1093-1099.
ABSTRACT | FULL TEXT  

Apolipoprotein E {epsilon}4 Count Affects Age at Onset of Alzheimer Disease, but Not Lifetime Susceptibility: The Cache County Study
Khachaturian et al.
Arch Gen Psychiatry 2004;61:518-524.
ABSTRACT | FULL TEXT  

Meta-Analysis of the Association of the Cathepsin D Ala224Val Gene Polymorphism with the Risk of Alzheimer's Disease: A HuGE Gene-Disease Association Review
Ntais et al.
Am J Epidemiol 2004;159:527-536.
ABSTRACT | FULL TEXT  

Essentials of the Proper Diagnoses of Mild Cognitive Impairment, Dementia, and Major Subtypes of Dementia
Knopman et al.
Mayo Clin Proc. 2003;78:1290-1308.
ABSTRACT  

Alzheimer Disease in the US Population: Prevalence Estimates Using the 2000 Census
Hebert et al.
Arch Neurol 2003;60:1119-1122.
ABSTRACT | FULL TEXT  

Incidence of Alzheimer Disease in a Biracial Urban Community: Relation to Apolipoprotein E Allele Status
Evans et al.
Arch Neurol 2003;60:185-189.
ABSTRACT | FULL TEXT  

Familial Patterns of Risk in Very Late-Onset Alzheimer Disease
Silverman et al.
Arch Gen Psychiatry 2003;60:190-197.
ABSTRACT | FULL TEXT  

Dementia and Alzheimer Disease Incidence: A Prospective Cohort Study
Kukull et al.
Arch Neurol 2002;59:1737-1746.
ABSTRACT | FULL TEXT  

Association of Incident Alzheimer Disease and Blood Pressure Measured From 13 Years Before to 2 Years After Diagnosis in a Large Community Study
Morris et al.
Arch Neurol 2001;58:1640-1646.
ABSTRACT | FULL TEXT  

Practice parameter: Early detection of dementia: Mild cognitive impairment (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology
Petersen et al.
Neurology 2001;56:1133-1142.
ABSTRACT | FULL TEXT  

Practice parameter: Diagnosis of dementia (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology
Knopman et al.
Neurology 2001;56:1143-1153.
ABSTRACT | FULL TEXT  

Cognitive Functional Status of Age-Confirmed Centenarians in a Population-Based Study
Silver et al.
Journals of Gerontology Series B: Psychological Sciences and Social Science 2001;56:P134-P140.
ABSTRACT | FULL TEXT  

Incidence of Dementia and Alzheimer Disease in 2 Communities: Yoruba Residing in Ibadan, Nigeria, and African Americans Residing in Indianapolis, Indiana
Hendrie et al.
JAMA 2001;285:739-747.
ABSTRACT | FULL TEXT  

Is the Risk of Developing Alzheimer's Disease Greater for Women than for Men?
Hebert et al.
Am J Epidemiol 2001;153:132-136.
ABSTRACT | FULL TEXT  

Incidence of AD in African-Americans, Caribbean Hispanics, and Caucasians in northern Manhattan
Tang et al.
Neurology 2001;56:49-56.
ABSTRACT | FULL TEXT  

The biphasic pattern of age-specific malignant brain tumor mortality rates
Riggs
Neurology 2000;55:750-753.
ABSTRACT | FULL TEXT  

The incidence of dementia in Canada
Neurology 2000;55:66-73.
ABSTRACT | FULL TEXT  

Age-specific incidence rates of Alzheimer's disease: The Baltimore Longitudinal Study of Aging
Kawas et al.
Neurology 2000;54:2072-2077.
ABSTRACT | FULL TEXT  

Smoking, drinking, and incident cognitive impairment: a cohort community based study included in the Gospel Oak project
Cervilla et al.
J. Neurol. Neurosurg. Psychiatry 2000;68:622-626.
ABSTRACT | FULL TEXT  

Ten-year incidence of dementia in a rural elderly US community population: The MoVIES Project
Ganguli et al.
Neurology 2000;54:1109-1116.
ABSTRACT | FULL TEXT  

Gender differences in the incidence of AD and vascular dementia: The EURODEM Studies
Andersen et al.
Neurology 1999;53:1992-1992.
ABSTRACT | FULL TEXT  

Treatment of Alzheimer's Disease
Mayeux and Sano
NEJM 1999;341:1670-1679.
FULL TEXT  

The Epidemiology of Common Late-Life Mental Disorders in the Community: Themes for the New Century
Gallo and Lebowitz
Psychiatr. Serv. 1999;50:1158-1166.
ABSTRACT | FULL TEXT  

Case 12-1999- A 67-Year-Old Man with Three Years of Dementia
Drachman and Newell
NEJM 1999;340:1269-1277.
FULL TEXT  

Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment
Jack et al.
Neurology 1999;52:1397-1397.
ABSTRACT | FULL TEXT  

Cognitive Decline in Adulthood: An 11.5-Year Follow-Up of the Baltimore Epidemiologic Catchment Area Study
Lyketsos et al.
Am. J. Psychiatry 1999;156:58-65.
ABSTRACT | FULL TEXT  

Rates and risk factors for dementia and Alzheimer's disease: Results from EURODEM pooled analyses
Launer et al.
Neurology 1999;52:78-78.
ABSTRACT | FULL TEXT  

The Relationships Between Age, Sex, and the Incidence of Dementia and Alzheimer Disease: A Meta-analysis
Gao et al.
Arch Gen Psychiatry 1998;55:809-815.
ABSTRACT | FULL TEXT  

Preserving Selves: Identity Work and Dementia
Vittoria
Research on Aging 1998;20:91-136.
ABSTRACT  

Education and Other Measures of Socioeconomic Status and Risk of Incident Alzheimer Disease in a Defined Population of Older Persons
Evans et al.
Arch Neurol 1997;54:1399-1405.
ABSTRACT  

Apolipoprotein E {epsilon}4 and Incidence of Alzheimer Disease in a Community Population of Older Persons
Evans et al.
JAMA 1997;277:822-824.
ABSTRACT