You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT JAMA
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 273 No. 20, May 24, 1995 TABLE OF CONTENTS
  JAMA
  •  Online Features
  ARTICLE
 This Article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in JAMA

Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis

J. Everhart and D. Wright
Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Md 20892-6600, USA.

OBJECTIVE--To evaluate diabetes mellitus as a risk factor for pancreatic cancer with the consideration that diabetes may also be a consequence of pancreatic cancer. DATA SOURCES--Pertinent studies of diabetes mellitus and pancreatic cancer published between 1975 and 1994 were identified from a MEDLINE search and from citations in articles and books. STUDY SELECTION--Twenty of a total of 30 case-control and cohort studies met the two inclusion criteria: cases with a duration of diabetes of at least 1 year prior to either pancreatic cancer diagnosis or death and the ability to calculate an appropriate relative risk (RR) estimate and variance. DATA EXTRACTION AND SYNTHESIS--The pooled RR and 95% confidence interval (CI) of pancreatic cancer for diabetics relative to nondiabetics was 2.1 (1.6 to 2.8). There was a tendency for a higher RR for the nine cohort studies (RR, 2.6; 95% CI, 1.6 to 4.1) than for the 11 case-control studies (RR, 1.8; 95% CI, 1.1 to 2.7). Requiring diabetes duration of at least 5 years resulted in an RR of 2.0 (95% CI, 1.2 to 3.2). CONCLUSION--Pancreatic cancer occurs with increased frequency among persons with long-standing diabetes.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Proliferation of Colo-357 Pancreatic Carcinoma Cells and Survival of Patients With Pancreatic Carcinoma Are Not Altered by Insulin Glargine
Erbel et al.
Diabetes Care 2008;31:1105-1111.
ABSTRACT | FULL TEXT  

Serum Prostate-Specific Antigen Levels in Men With Type 2 Diabetes
Fukui et al.
Diabetes Care 2008;31:930-931.
ABSTRACT | FULL TEXT  

Cardiorespiratory Fitness as a Predictor of Cancer Mortality Among Men With Pre-Diabetes and Diabetes
Thompson et al.
Diabetes Care 2008;31:764-769.
ABSTRACT | FULL TEXT  

Advances in counselling and surveillance of patients at risk for pancreatic cancer
Brand et al.
Gut 2007;56:1460-1469.
ABSTRACT | FULL TEXT  

Prediagnostic Plasma C-Peptide and Pancreatic Cancer Risk in Men and Women
Michaud et al.
Cancer Epidemiol. Biomarkers Prev. 2007;16:2101-2109.
ABSTRACT | FULL TEXT  

Association between glycosylated hemoglobin and cancer risk: a New Zealand linkage study
Travier et al.
Ann Oncol 2007;18:1414-1419.
ABSTRACT | FULL TEXT  

A Prospective Study of Periodontal Disease and Pancreatic Cancer in US Male Health Professionals
Michaud et al.
JNCI J Natl Cancer Inst 2007;99:171-175.
ABSTRACT | FULL TEXT  

Vegetable Intake and Pancreatic Cancer Risk: The Multiethnic Cohort Study
Nothlings et al.
Am J Epidemiol 2007;165:138-147.
ABSTRACT | FULL TEXT  

A Meta-analysis of Diabetes Mellitus and the Risk of Prostate Cancer.
Kasper and Giovannucci
Cancer Epidemiol. Biomarkers Prev. 2006;15:2056-2062.
ABSTRACT | FULL TEXT  

Vitamin d intake and the risk for pancreatic cancer in two cohort studies.
Skinner et al.
Cancer Epidemiol. Biomarkers Prev. 2006;15:1688-1695.
ABSTRACT | FULL TEXT  

Diabetes mellitus and pancreatic cancer in a population-based case-control study in the san francisco bay area, california.
Wang et al.
Cancer Epidemiol. Biomarkers Prev. 2006;15:1458-1463.
ABSTRACT | FULL TEXT  

Genetics and biology of pancreatic ductal adenocarcinoma.
Hezel et al.
Genes Dev. 2006;20:1218-1249.
ABSTRACT | FULL TEXT  

Increased Cancer-Related Mortality for Patients With Type 2 Diabetes Who Use Sulfonylureas or Insulin
Bowker et al.
Diabetes Care 2006;29:254-258.
ABSTRACT | FULL TEXT  

Meat and Fat Intake as Risk Factors for Pancreatic Cancer: The Multiethnic Cohort Study
Nothlings et al.
JNCI J Natl Cancer Inst 2005;97:1458-1465.
ABSTRACT | FULL TEXT  

The Association of Body Mass Index and Pancreatic Cancer in Residents of Southeastern Michigan, 1996-1999
Fryzek et al.
Am J Epidemiol 2005;162:222-228.
ABSTRACT | FULL TEXT  

Differences in Survival by Histologic Type of Pancreatic Cancer
Fesinmeyer et al.
Cancer Epidemiol. Biomarkers Prev. 2005;14:1766-1773.
ABSTRACT | FULL TEXT  

Dietary Patterns and Pancreatic Cancer Risk in Men and Women
Michaud et al.
JNCI J Natl Cancer Inst 2005;97:518-524.
ABSTRACT | FULL TEXT  

Cigarette smoking accelerates progression of alcoholic chronic pancreatitis
Maisonneuve et al.
Gut 2005;54:510-514.
ABSTRACT | FULL TEXT  

Impact of Fasting Plasma Glucose Levels on Gastric Cancer Incidence in a General Japanese Population: The Hisayama Study
Yamagata et al.
Diabetes Care 2005;28:789-794.
ABSTRACT | FULL TEXT  

Obesity, Recreational Physical Activity, and Risk of Pancreatic Cancer In a Large U.S. Cohort
Patel et al.
Cancer Epidemiol. Biomarkers Prev. 2005;14:459-466.
ABSTRACT | FULL TEXT  

Fasting Serum Glucose Level and Cancer Risk in Korean Men and Women
Jee et al.
JAMA 2005;293:194-202.
ABSTRACT | FULL TEXT  

A Prospective Study of Folate Intake and the Risk of Pancreatic Cancer in Men and Women
Skinner et al.
Am J Epidemiol 2004;160:248-258.
ABSTRACT | FULL TEXT  

Diabetes Mellitus as a Predictor of Cancer Mortality in a Large Cohort of US Adults
Coughlin et al.
Am J Epidemiol 2004;159:1160-1167.
ABSTRACT | FULL TEXT  

Epidemiology and Prevention of Pancreatic Cancer
Lowenfels and Maisonneuve
Jpn J Clin Oncol 2004;34:238-244.
ABSTRACT | FULL TEXT  

Prior History of Allergies and Pancreatic Cancer in the San Francisco Bay Area
Holly et al.
Am J Epidemiol 2003;158:432-441.
ABSTRACT | FULL TEXT  

Dietary Meat, Dairy Products, Fat, and Cholesterol and Pancreatic Cancer Risk in a Prospective Study
Michaud et al.
Am J Epidemiol 2003;157:1115-1125.
ABSTRACT | FULL TEXT  

Parity, Reproductive Factors, and the Risk of Pancreatic Cancer in Women
Skinner et al.
Cancer Epidemiol. Biomarkers Prev. 2003;12:433-438.
ABSTRACT | FULL TEXT  

Epidemiology of pancreatic cancer in Japan: a nested case-control study from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC)
Inoue et al.
Int J Epidemiol 2003;32:257-262.
ABSTRACT | FULL TEXT  

Urinary Cadmium, Impaired Fasting Glucose, and Diabetes in the NHANES III
Schwartz et al.
Diabetes Care 2003;26:468-470.
ABSTRACT | FULL TEXT  

Dietary Sugar, Glycemic Load, and Pancreatic Cancer Risk in a Prospective Study
Michaud et al.
JNCI J Natl Cancer Inst 2002;94:1293-1300.
ABSTRACT | FULL TEXT  

Risk of pancreatic cancer after cholecystectomy: a cohort study in Sweden
Ye et al.
Gut 2001;49:678-681.
ABSTRACT | FULL TEXT  

Physical Activity, Obesity, Height, and the Risk of Pancreatic Cancer
Michaud et al.
JAMA 2001;286:921-929.
ABSTRACT | FULL TEXT  

Is Pancreatic Cancer a Preventable Disease?
Gapstur and Gann
JAMA 2001;286:967-968.
FULL TEXT  

Coffee and Alcohol Consumption and the Risk of Pancreatic Cancer in Two Prospective United States Cohorts
Michaud et al.
Cancer Epidemiol. Biomarkers Prev. 2001;10:429-437.
ABSTRACT | FULL TEXT  

Hyperinsulinemia Predicts Fatal Liver Cancer but Is Inversely Associated With Fatal Cancer at Some Other Sites: The Paris Prospective Study
Balkau et al.
Diabetes Care 2001;24:843-849.
ABSTRACT | FULL TEXT  

Inherited Predisposition to Pancreatic Adenocarcinoma: Role of Family History and Germ-Line p16, BRCA1, and BRCA2 Mutations
Lal et al.
Cancer Res. 2000;60:409-416.
ABSTRACT | FULL TEXT  

Abdominal US for Diagnosis of Pancreatic Tumor: Prospective Cohort Analysis
Karlson et al.
Radiology 1999;213:107-111.
ABSTRACT | FULL TEXT  

Classic diseases revisited: Pancreatic cancer: any prospects for prevention?
Hart
Postgrad. Med. J. 1999;75:521-526.
ABSTRACT | FULL TEXT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1995 American Medical Association. All Rights Reserved.