A randomized trial comparing octylcyanoacrylate tissue adhesive and sutures in the management of lacerations
J. Quinn, G. Wells, T. Sutcliffe, M. Jarmuske, J. Maw, I. Stiell and P. Johns
Section of Emergency Medicine, University of Michigan, Ann Arbor 48109-0303, USA. jaquinn@umich.edu
OBJECTIVE: To assess the effectiveness of a new tissue adhesive for
laceration closure. DESIGN: A prospective, randomized controlled trial.
SETTING: An adult teaching hospital. PARTICIPANTS: One hundred thirty
patients with 136 lacerations who consented to enrollment during a 5-month
period. The lacerations included all eligible nonmucosal facial
lacerations, as well as selected extremity and torso lacerations (not on
hands, feet, or joints). One hundred six lacerations were available for
early follow-up, and 98 were available for 3-month evaluation.
INTERVENTIONS: Lacerations were randomly allocated to have skin closure
with octylcyanoacrylate adhesive or monofilament suture. MAIN OUTCOME
MEASURE: A 3-month photograph of the wound was assigned a cosmesis score on
a previously validated 100-mm visual analog cosmesis scale by a plastic
surgeon who was unaware of the method of wound closure. RESULTS: There were
no differences in the mean visual analog cosmesis scores (67 mm for
octylcyanoacrylate vs 68 mm for sutures; P=.65). Similarly, there was no
difference in the percentage of early (80% vs 82%; P=.80) or late (72% vs
75%; P=.74) optimal wound evaluation scores. The tissue adhesive was a
faster method of wound repair (3.6 vs 12.4 minutes; P<.001) as well as
being less painful (visual analog pain scores, 7.2 vs 18.0 mm; P<.001).
CONCLUSIONS: Octylcyanoacrylate tissue adhesive effectively closes selected
lacerations. This relatively painless and fast method of wound repair can
replace the need for suturing several million lacerations each year.
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Octyl-2-Cyanoacrylate Use for Defect Closure After Wound Dehiscence
Nouri et al.
Arch Dermatol 2004;140:1541-1542.
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Zempsky et al.
Pediatrics 2004;114:1348-1356.
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The management of facial injuries in rugby union
Hayton et al.
Br. J. Sports. Med. 2004;38:314-317.
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Use of tissue adhesives in sport? A new application in international ice hockey * Commentary
Branfield and Aubry
Br. J. Sports. Med. 2004;38:95-96.
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A Light-Activated Surgical Adhesive Technique for Sutureless Ophthalmic Surgery
Bloom et al.
Arch Ophthalmol 2003;121:1591-1595.
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Tissue adhesive with adhesive strips for wound closure
Atkinson
Emerg. Med. J. 2003;20:498-498.
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Use of tissue adhesives in the management of paediatric lacerations
Mattick
Emerg. Med. J. 2002;19:382-385.
ABSTRACT
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A randomised, controlled trial comparing a tissue adhesive (2-octylcyanoacrylate) with adhesive strips (Steristrips) for paediatric laceration repair
Mattick et al.
Emerg. Med. J. 2002;19:405-407.
ABSTRACT
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A Prospective Comparison of Octyl Cyanoacrylate Tissue Adhesive (Dermabond) and Suture for the Closure of Excisional Wounds in Children and Adolescents
Bernard et al.
Arch Dermatol 2001;137:1177-1180.
ABSTRACT
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Evaluation of a bioadhesive device for the management of aphthous ulcers
KUTCHER et al.
Journal of the American Dental Association 2001;132:368-376.
ABSTRACT
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Discussion Sections in Reports of Controlled Trials Published in General Medical Journals: Islands in Search of Continents?
Clarke and Chalmers
JAMA 1998;280:280-282.
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Evaluation and Management of Traumatic Lacerations
Singer et al.
NEJM 1997;337:1142-1148.
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Cyanoacrylate Adhesive for Lacerations
Journal Watch Dermatology 1997;1997:12-12.
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SUPER GLUE FOR LACERATIONS: ENCOURAGING DATA
JWatch General 1997;1997:2-2.
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