Deficiency of the INCL protein Ppt1 results in changes in ectopic F1-ATP synthase and altered cholesterol metabolism
Lyly et al.
Hum Mol Genet 2008;17:1406-1417.
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Genetic tests for common diseases: new insights, old concerns
Melzer et al.
BMJ 2008;336:590-593.
FULL TEXT
Lack of Association Between Apolipoprotein E Polymorphism and Vascular Dementia in Koreans
Ki Woong Kim et al.
J Geriatr Psychiatry Neurol 2008;21:12-17.
ABSTRACT
Plasma amyloid {beta} protein is elevated in late-onset Alzheimer disease families
Ertekin-Taner et al.
Neurology 2008;70:596-606.
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MRI patterns of atrophy associated with progression to AD in amnestic mild cognitive impairment
Whitwell et al.
Neurology 2008;70:512-520.
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From the Cover: Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism
Mosconi et al.
Proc. Natl. Acad. Sci. USA 2007;104:19067-19072.
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Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease
Hamshere et al.
Hum Mol Genet 2007;16:2703-2712.
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Apolipoprotein E {varepsilon}4 Genotype and Gender: Effects on Memory
Sundermann et al.
AJGP 2007;15:869-878.
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BEYOND AMYLOID: The Next Generation of Alzheimer's Disease Therapeutics
Seabrook et al.
Mol. Interv. 2007;7:261-270.
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The Pathogenesis of Alzheimers Disease Is It a Lifelong "Calciumopathy"?
Stutzmann
Neuroscientist 2007;13:546-559.
ABSTRACT
Relation between smoking and risk of dementia and Alzheimer disease: The Rotterdam Study
Reitz et al.
Neurology 2007;69:998-1005.
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Cognitive Domain Decline in Healthy Apolipoprotein E {varepsilon}4 Homozygotes Before the Diagnosis of Mild Cognitive Impairment
Caselli et al.
Arch Neurol 2007;64:1306-1311.
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No association of CSF biomarkers with APOE{varepsilon}4, plaque and tangle burden in definite Alzheimer's disease
Engelborghs et al.
Brain 2007;130:2320-2326.
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Dopamine Genes and Schizophrenia: Case Closed or Evidence Pending?
Talkowski et al.
Schizophr Bull 2007;33:1071-1081.
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Plasma Homocysteine Is Associated with the Risk of Mild Cognitive Impairment in an Elderly Korean Population
Kim et al.
J. Nutr. 2007;137:2093-2097.
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Differences in the Association Between Apolipoprotein E Genotype and Mortality Across Populations
Ewbank
J. Gerontol. A Biol. Sci. Med. Sci. 2007;62:899-907.
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Neuropsychological Measures in Normal Individuals That Predict Subsequent Cognitive Decline
Blacker et al.
Arch Neurol 2007;64:862-871.
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Invited Commentary: When Bad Genes Look Good--APOE*E4, Cognitive Decline, and Diagnostic Thresholds
Glymour
Am J Epidemiol 2007;165:1239-1246.
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Prevalence of dementia in Chamorros on Guam: Relationship to age, gender, education, and APOE
Galasko et al.
Neurology 2007;68:1772-1781.
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Apolipoprotein E genotypes and their relation to lipid levels in a rural South African population 1
Masemola et al.
Scand J Public Health 2007;35:60-65.
ABSTRACT
Ethnicity-specific Gene-Gene Interaction between IL-13 and IL-4R{alpha} among African Americans with Asthma
Battle et al.
Am. J. Respir. Crit. Care Med. 2007;175:881-887.
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How migraines impact cognitive function: Findings from the Baltimore ECA
Kalaydjian et al.
Neurology 2007;68:1417-1424.
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Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus
Graham et al.
Proc. Natl. Acad. Sci. USA 2007;104:6758-6763.
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Measuring the Risk of Alzheimer Disease
Rosenberg
Arch Neurol 2007;64:479-480.
FULL TEXT
Cholesterol and Triglycerides Moderate the Effect of Apolipoprotein E on Memory Functioning in Older Adults
de Frias et al.
J. Gerontol. B Psychol. Sci. Soc. Sci. 2007;62:P112-P118.
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Less Atherosclerosis and Lower Blood Pressure for a Meaningful Life Perspective With More Brain
Staessen et al.
Hypertension 2007;49:389-400.
FULL TEXT
Linking Brain Imaging and Genomics in the Study of Alzheimer's Disease and Aging
REIMAN
Ann. N. Y. Acad. Sci. 2007;1097:94-113.
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Two sites in the MAPT region confer genetic risk for Guam ALS/PDC and dementia
Sundar et al.
Hum Mol Genet 2007;16:295-306.
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The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between {beta}-amyloid production and tau phosphorylation in Alzheimer disease
Kimura et al.
Hum Mol Genet 2007;16:15-23.
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The Effect of Borderline Diabetes on the Risk of Dementia and Alzheimer's Disease
Xu et al.
Diabetes 2007;56:211-216.
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Lower Prevalence of Epsilon 4 Allele of Apolipoprotein E Gene in Healthy, Longer-Lived Individuals of Hellenic Origin
Stakias et al.
J. Gerontol. A Biol. Sci. Med. Sci. 2006;61:1228-1231.
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Human telomere biology: pitfalls of moving from the laboratory to epidemiology
Aviv et al.
Int J Epidemiol 2006;35:1424-1429.
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Primary prevention trials in Alzheimer disease.
Green and DeKosky
Neurology 2006;67:S2-S5.
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Prevention trials in Alzheimer disease: One step forward?
Touchon et al.
Neurology 2006;67:S21-S22.
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Activation of estrogen receptor {alpha} increases and estrogen receptor beta decreases apolipoprotein E expression in hippocampus in vitro and in vivo
Wang et al.
Proc. Natl. Acad. Sci. USA 2006;103:16983-16988.
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100 Years and Counting: Prospects for Defeating Alzheimer's Disease
Roberson and Mucke
Science 2006;314:781-784.
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Ashkenazi Jews and Breast Cancer: The Consequences of Linking Ethnic Identity to Genetic Disease
Brandt-Rauf et al.
Am. J. Public Health 2006;96:1979-1988.
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Apolipoprotein E {varepsilon}4 and Age at Onset of Sporadic and Familial Alzheimer Disease in Caribbean Hispanics
Olarte et al.
Arch Neurol 2006;63:1586-1590.
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Regional brain atrophy in cognitively intact adults with a single APOE {varepsilon}4 allele.
Wishart et al.
Neurology 2006;67:1221-1224.
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Implications of Small Effect Sizes of Individual Genetic Variants on the Design and Interpretation of Genetic Association Studies of Complex Diseases
Ioannidis et al.
Am J Epidemiol 2006;164:609-614.
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Geographic Ancestry, Angiotensinogen Gene Polymorphism, and Cardiovascular Risk
Castellano
Hypertension 2006;48:562-563.
FULL TEXT
Systematic review and meta-analysis of the association between complementary factor H Y402H polymorphisms and age-related macular degeneration
Thakkinstian et al.
Hum Mol Genet 2006;15:2784-2790.
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Hippocampal volume, brain atrophy, and APOE genotype after traumatic brain injury.
Isoniemi et al.
Neurology 2006;67:756-760.
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Genetics and Dementia Nosology
Blacker and Lovestone
J Geriatr Psychiatry Neurol 2006;19:186-191.
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"A Gene for. . .":The Nature of Gene Action in Psychiatric Disorders
Kendler
Focus 2006;4:391.
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Apolipoprotein E {varepsilon}4 and impaired episodic memory in community-dwelling elderly people: a marked sex difference. The Hordaland Health Study
Lehmann et al.
J. Neurol. Neurosurg. Psychiatry 2006;77:902-908.
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When it runs in the family: putting susceptibility genes in perspective
Lock et al.
Public Understanding of Science 2006;15:277-300.
ABSTRACT
Effect of apolipoprotein e on the cerebral load of latent herpes simplex virus type 1 DNA.
Burgos et al.
J. Virol. 2006;80:5383-5387.
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Commentary: Grading the credibility of molecular evidence for complex diseases
Ioannidis
Int J Epidemiol 2006;35:572-578.
FULL TEXT
Structural and Functional Variations in Human Apolipoprotein E3 and E4
Chou et al.
J. Biol. Chem. 2006;281:13333-13344.
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Profile and Regulation of Apolipoprotein E (ApoE) Expression in the CNS in Mice with Targeting of Green Fluorescent Protein Gene to the ApoE Locus.
Xu et al.
J. Neurosci. 2006;26:4985-4994.
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Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice.
Esposito et al.
J. Neurosci. 2006;26:5167-5179.
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APOE epsilon variation in multiple sclerosis susceptibility and disease severity: Some answers
Burwick et al.
Neurology 2006;66:1373-1383.
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Reduced functional brain activity response in cognitively intact apolipoprotein E {varepsilon}4 carriers
Lind et al.
Brain 2006;129:1240-1248.
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The distribution of apolipoprotein E alleles in Scottish perinatal deaths
Becher et al.
J. Med. Genet. 2006;43:414-418.
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Inaugural Article: Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer's disease
Mahley et al.
Proc. Natl. Acad. Sci. USA 2006;103:5644-5651.
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Clinical trials in mild cognitive impairment: lessons for the future
Jelic et al.
J. Neurol. Neurosurg. Psychiatry 2006;77:429-438.
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Race and ethnicity in the era of emerging pharmacogenomics.
Harty et al.
J Clin Pharmacol 2006;46:405-407.
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Association of apolipoprotein e genotype and Alzheimer disease in african americans.
Murrell et al.
Arch Neurol 2006;63:431-434.
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Combination of Clinical and Neuropsychologic Information as a Better Predictor of the Progression to Alzheimer Disease in Questionable Dementia Individuals
Lee et al.
AJGP 2006;14:130-138.
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Role of Genes and Environments for Explaining Alzheimer Disease
Gatz et al.
Arch Gen Psychiatry 2006;63:168-174.
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Cholesterol, APOE genotype, and Alzheimer disease: An epidemiologic study of Nigerian Yoruba
Hall et al.
Neurology 2006;66:223-227.
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Heart Disease and Dementia: A Population-based Study
Bursi et al.
Am J Epidemiol 2006;163:135-141.
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Polymorphisms in the PON gene cluster are associated with Alzheimer disease
Erlich et al.
Hum Mol Genet 2006;15:77-85.
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Apolipoprotein E Genotype and Age-Related Myelin Breakdown in Healthy Individuals: Implications for Cognitive Decline and Dementia
Bartzokis et al.
Arch Gen Psychiatry 2006;63:63-72.
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Apolipoprotein E Genotype Modifies the Phenotype of Alzheimer Disease
Schott et al.
Arch Neurol 2006;63:155-156.
FULL TEXT
APOE alleles predict the rate of cognitive decline in Alzheimer disease: A nonlinear model
Martins et al.
Neurology 2005;65:1888-1893.
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Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity
Chang et al.
Proc. Natl. Acad. Sci. USA 2005;102:18694-18699.
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Apolipoprotein (apo) E4 enhances amyloid {beta} peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target
Ye et al.
Proc. Natl. Acad. Sci. USA 2005;102:18700-18705.
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Children of Alzheimer Patients: An Overview
Jarvik and Blazer
J Geriatr Psychiatry Neurol 2005;18:181-186.
Genetic Risk Assessment for Adult Children of People With Alzheimer's Disease: The Risk Evaluation and Education for Alzheimer's Disease (REVEAL) Study
Roberts et al.
J Geriatr Psychiatry Neurol 2005;18:250-255.
ABSTRACT
Looking Forward in Geriatric Anxiety and Depression: Implications of Basic Science for the Future
Gershenfeld et al.
AJGP 2005;13:1027-1040.
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Genetic Heterogeneity in Association of the SUMO4 M55V Variant With Susceptibility to Type 1 Diabetes
Noso et al.
Diabetes 2005;54:3582-3586.
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Genetic susceptibility for Alzheimer's disease: Why did adult offspring seek testing?
Hurley et al.
AM J ALZHEIMERS DIS OTHER DEMEN 2005;20:374-381.
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Modulation of Apolipoprotein E Structure by Domain Interaction: DIFFERENCES IN LIPID-BOUND AND LIPID-FREE FORMS
Hatters et al.
J. Biol. Chem. 2005;280:34288-34295.
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Shared genetic risk factors for obstructive sleep apnea and obesity
Patel
J. Appl. Physiol. 2005;99:1600-1606.
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Complexity of Work and Risk of Alzheimer's Disease: A Population-Based Study of Swedish Twins
Andel et al.
J. Gerontol. B Psychol. Sci. Soc. Sci. 2005;60:P251-P258.
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Firing up the nature/nurture controversy: bioethics and genetic determinism
de Melo-Martin
J. Med. Ethics 2005;31:526-530.
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Genetic Influences on Health: Does Race Matter?
Bamshad
JAMA 2005;294:937-946.
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Large Meta-Analysis Establishes the ACE Insertion-Deletion Polymorphism as a Marker of Alzheimer's Disease
Lehmann et al.
Am J Epidemiol 2005;162:305-317.
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Subjective Memory Complaints With and Without Objective Memory Impairment: Relationship With Risk Factors for Dementia
Lautenschlager et al.
AJGP 2005;13:731-734.
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APOE, vascular pathology, and the AD brain
Yip et al.
Neurology 2005;65:259-265.
ABSTRACT
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Is there a relation between APOE expression and brain amyloid load in Alzheimer's disease?
Lambert et al.
J. Neurol. Neurosurg. Psychiatry 2005;76:928-933.
ABSTRACT
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"A Gene for...": The Nature of Gene Action in Psychiatric Disorders
Kendler
Am. J. Psychiatry 2005;162:1243-1252.
ABSTRACT
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From The Cover: Correlations between apolipoprotein E {epsilon}4 gene dose and brain-imaging measurements of regional hypometabolism
Reiman et al.
Proc. Natl. Acad. Sci. USA 2005;102:8299-8302.
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Sex, Apolipoprotein E {varepsilon}4 Status, and Hippocampal Volume in Mild Cognitive Impairment
Fleisher et al.
Arch Neurol 2005;62:953-957.
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Sex Differences in the Clinical Manifestations of Alzheimer Disease Pathology
Barnes et al.
Arch Gen Psychiatry 2005;62:685-691.
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Apolipoprotein E, B Vitamins, and Cognitive Function in Older Adults
Bunce et al.
J. Gerontol. B Psychol. Sci. Soc. Sci. 2005;60:P41-P48.
ABSTRACT
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Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease
Lane and Farlow
J. Lipid Res. 2005;46:949-968.
ABSTRACT
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Earlier Onset of Alzheimer Disease Symptoms in Latino Individuals Compared With Anglo Individuals
Clark et al.
Arch Neurol 2005;62:774-778.
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Variability of Familial Risk of Alzheimer Disease Across the Late Life Span
Silverman et al.
Arch Gen Psychiatry 2005;62:565-573.
ABSTRACT
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Family-Based Association between Alzheimer's Disease and Variants in UBQLN1
Bertram et al.
NEJM 2005;352:884-894.
ABSTRACT
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Cholesterol and apolipoprotein E in Alzheimer's disease
Reiss
AM J ALZHEIMERS DIS OTHER DEMEN 2005;20:91-96.
ABSTRACT
Alzheimer's disease: genetic variables and risk
Secko
CMAJ 2005;172:627-627.
FULL TEXT
Mutation Screening and Association Study of the Neprilysin Gene in Sporadic Alzheimer's Disease in Chinese Persons
Shi et al.
J. Gerontol. A Biol. Sci. Med. Sci. 2005;60:301-306.
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Apolipoprotein {varepsilon}4 Allele and Problems With Orientation Are Associated With a Persistent Decline in Cognition in Community-Dwelling Elderly Persons
Wayne et al.
J. Gerontol. A Biol. Sci. Med. Sci. 2005;60:375-379.
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