Immunologic aspects of renal disease
J. L. Ambrus Jr and N. R. Sridhar
The kidney can become involved in immune-mediated diseases through 3
mechanisms. It can be the primary target of antibody-mediated injury.
Good-pasture syndrome, with antibodies directed at the glomerular basement
membrane, is an example of this type. The kidney can be injured by immune
complexes that are trapped in the kidney and cause local inflammation.
Examples include systemic lupus erythematosus and IgA nephropathies.
Finally, the kidney can be injured by immune responses initiated in other
organs. In Wegener granulomatosis, inflammation begins in the airway but
results in glomerulonephritis. Currently available therapies lack efficacy
and specificity. New therapies based on pathophysiology are being developed
in animal models.
