Tumor immunology
S. Shu, G. E. Plautz, J. C. Krauss and A. E. Chang
Malignant tumors express antigens that may stimulate and serve as targets
for antitumor immunity. Virally induced tumors usually contain integrated
proviral genomes in theircellulargenomes and often express viral
genome-encoded proteins that may stimulate specific host immune responses.
Antigens unique to individual tumors that stimulate specific rejection of
transplanted tumors have been demonstrated only in experimental animals.
Other tumor antigens that potentially can stimulate immune responses are
shared by different tumors. These include products of mutated or rearranged
oncogenes or tumor-suppressor genes. Tumors may also overexpress tissue
differentiation antigens or embryonic antigens, which also have the
potential to be recognized by the immune system. The recent identification
of tumor antigens recognized by cytotoxic T cells opens up new
possibilities for constructing chemically defined antigens for specific
immunotherapy. Treatment of malignant tumors in humans by immunologic
approaches, although theoretically attractive, has not yet succeeded on a
large scale. Important progress in immunotherapy of cancer is emerging with
several different treatment modalities.
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Tumor Immunity within the Central Nervous System Stimulated by Recombinant Listeria monocytogenes Vaccination
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Cochlovius et al.
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Korbelik and Dougherty
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