ImmunopharmacologyImmunomodulation and Immunotherapy
Mark Ballow, MD;
Robert Nelson, MD
JAMA. 1997;278(22):2008-2017.
Abstract
Immunopharmacology has changed dramatically over the past 25 years. Although a variety of traditional nonspecific immunosuppressive drug therapies are available for the treatment of autoimmune disease and organ transplantation rejection, with advances in cell biology and monoclonal antibody technology, a highly specific antibody can be engineered to cell surface determinants on immune cells or tumors or to neutralize inflammatory and immune mediators from an immune response. Many of these modalities are still in early phases of study for the treatment of autoimmune disease. In addition to therapies that suppress immune responses, advances in molecular biology have led to new agents and methods to enhance immune responses and correct immune deficits, such as growth factor replacement and cytokine therapies. Finally, gene therapy is a method for the long-term treatment of disorders in which a defective gene leads to disease.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
RELATED LETTER
Interferon for Melanoma: Another Application of Immunopharmacology
Christopher Nauman and Mark Ballow
JAMA. 1998;279(16):1263.
EXTRACT
| FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Immunomodulatory Activity of Oenothein B Isolated from Epilobium angustifolium
Schepetkin et al.
J. Immunol. 2009;183:6754-6766.
ABSTRACT
| FULL TEXT
Modulation of Endotoxin- and Enterotoxin-Induced Cytokine Release by In Vivo Treatment with beta -(1,6)-Branched beta -(1,3)-Glucan
Soltys and Quinn
Infect. Immun. 1999;67:244-252.
ABSTRACT
| FULL TEXT
Interferon for Melanoma: Another Application of Immunopharmacology
Nauman and Ballow
JAMA 1998;279:1263-1263.
FULL TEXT
|
