You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT JAMA
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 279 No. 4, January 28, 1998 TABLE OF CONTENTS
  JAMA
  •  Online Features
  Original Contribution
 This Article
 •Full text
 •PDF
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Citing articles on Web of Science (100)
 •Contact me when this article is cited
 Related Content
 •Related letter
 •Similar articles in JAMA
 Topic Collections
 •Oncology
 •Oncology, Other
 •Alert me on articles by topic
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit Add to Technorati Add to Twitter What's this?

Contamination of Poliovirus Vaccines With Simian Virus 40 (1955-1963) and Subsequent Cancer Rates

Howard D. Strickler, MD, MPH; Philip S. Rosenberg, PhD; Susan S. Devesa, PhD; Joan Hertel; Joseph F. Fraumeni, Jr, MD; James J. Goedert, MD

JAMA. 1998;279:292-295.

Context.— Poliovirus vaccine contaminated with live simian virus 40 (SV40), a macaque polyomavirus that is tumorigenic in rodents, was used extensively in the United States between 1955 and 1963. Simian virus 40 DNA has recently been detected in several rare human tumors, including ependymomas, osteosarcomas, and mesotheliomas.

Objective.— To determine the risk of ependymoma, osteosarcoma, and mesothelioma among Americans who as children received SV40-contaminated poliovirus vaccine.

Design.— Retrospective cohort study using data from the Surveillance, Epidemiology, and End Results program (1973-1993) and the Connecticut Tumor Registry (1950-1969), as well as national mortality statistics (1947-1973).

Setting.— United States.

Participants.— Birth cohorts that were likely to have received SV40-contaminated poliovirus vaccine as infants, born 1956 through 1962 (60811730 person-years of observation); as children, born 1947 through 1952 (46430953 person-years); or that were unexposed, born 1964 through 1969 (44959979 person-years).

Main Outcome Measures.— Relative risk (RR) of each cancer among exposed compared with unexposed birth cohorts.

Results.— Age-specific cancer rates were generally low and were not significantly elevated in birth cohorts exposed to SV40-contaminated vaccine. Specifically, compared with the unexposed, the relative risk of ependymoma was not increased in the cohorts exposed as infants (RR, 1.06; 95% confidence interval [CI], 0.69-1.63), or as children (RR, 0.98; 95% CI, 0.57-1.69) nor did the exposed have an increased risk of all brain cancers. Osteosarcoma incidence also showed no relation to exposure as infants (RR, 0.87; 95% CI, 0.71-1.06) or children (RR, 0.85; 95% CI, 0.59-1.22). Last, mesotheliomas were not significantly associated with exposure, although the cohorts studied have not yet reached the age at which these tumors tend to occur.

Conclusions.— After more than 30 years of follow-up, exposure to SV40-contaminated poliovirus vaccine was not associated with significantly increased rates of ependymomas and other brain cancers, osteosarcomas, or mesotheliomas in the United States.


From the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Md (Drs Strickler, Rosenberg, Devesa, Fraumeni, and Goedert); and Information Management Systems (Ms Hertel), Rockville, Md.



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter     What's this?

RELATED LETTER

Simian Virus 40–Contaminated Polio Vaccine and Cancer Rates
Michael D. Innis, Howard D. Strickler, Philip S. Rosenberg, Susan S. Devesa, Joseph F. Fraumeni, Jr, and James J. Goedert
JAMA. 1998;280(17):1481-1482.
EXTRACT | FULL TEXT  


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Simian virus 40 and mesothelioma in Great Britain
Price et al.
Occup Med (Lond) 2007;57:564-568.
ABSTRACT | FULL TEXT  

A Novel SV40 TAg Transgenic Model of Asbestos-Induced Mesothelioma: Malignant Transformation Is Dose Dependent.
Robinson et al.
Cancer Res. 2006;66:10786-10794.
ABSTRACT | FULL TEXT  

Is There a Role for SV40 in Human Cancer?
Poulin and DeCaprio
JCO 2006;24:4356-4365.
ABSTRACT | FULL TEXT  

Poliovirus Vaccination during Pregnancy, Maternal Seroconversion to Simian Virus 40, and Risk of Childhood Cancer
Engels et al.
Am J Epidemiol 2004;160:306-316.
ABSTRACT | FULL TEXT  

Case-Control Study of Cancer among US Army Veterans Exposed to Simian Virus 40-contaminated Adenovirus Vaccine
Rollison et al.
Am J Epidemiol 2004;160:317-324.
ABSTRACT | FULL TEXT  

Emergent Human Pathogen Simian Virus 40 and Its Role in Cancer
Vilchez and Butel
Clin. Microbiol. Rev. 2004;17:495-508.
ABSTRACT | FULL TEXT  

Cancer Incidence in Denmark Following Exposure to Poliovirus Vaccine Contaminated With Simian Virus 40
Engels et al.
JNCI J Natl Cancer Inst 2003;95:532-539.
ABSTRACT | FULL TEXT  

Serological Cross-Reactivities between Antibodies to Simian Virus 40, BK Virus, and JC Virus Assessed by Virus-Like-Particle-Based Enzyme Immunoassays
Viscidi et al.
CVI 2003;10:278-285.
ABSTRACT | FULL TEXT  

Polio Vaccination and Risk of Brain Tumors in Adults: No Apparent Association
Brenner et al.
Cancer Epidemiol. Biomarkers Prev. 2003;12:177-178.
FULL TEXT  

Trends in U.S. Pleural Mesothelioma Incidence Rates Following Simian Virus 40 Contamination of Early Poliovirus Vaccines
Strickler et al.
JNCI J Natl Cancer Inst 2003;95:38-45.
ABSTRACT | FULL TEXT  

Epidemiology of primary brain tumors: Current concepts and review of the literature
Wrensch et al.
Neuro Oncol Duke 2002;4:278-299.
ABSTRACT  

A Multicenter Evaluation of Assays for Detection of SV40 DNA and Results in Masked Mesothelioma Specimens
Cancer Epidemiol. Biomarkers Prev. 2001;10:523-532.
ABSTRACT | FULL TEXT  

Infectious Disease Issues in Xenotransplantation
Boneva et al.
Clin. Microbiol. Rev. 2001;14:1-14.
ABSTRACT | FULL TEXT  

The RB2/p130 Gene: The Latest Weapon in the War against Lung Cancer?
Claudio et al.
Clin. Cancer Res. 2000;6:754-764.
ABSTRACT | FULL TEXT  

Antisense to SV40 Early Gene Region Induces Growth Arrest and Apoptosis in T-Antigen-positive Human Pleural Mesothelioma Cells
Waheed et al.
Cancer Res. 1999;59:6068-6073.
ABSTRACT | FULL TEXT  

Simian virus 40 and human pleural mesothelioma
JASANI; et al.
Thorax 1999;54:750b-750.
FULL TEXT  

Convicting a human tumor virus: Guilt by association?
Blaho and Aaronson
Proc. Natl. Acad. Sci. USA 1999;96:7619-7621.
FULL TEXT  

Asbestos induction of extended lifespan in normal human mesothelial cells: interindividual susceptibility and SV40 T antigen
Xu et al.
Carcinogenesis 1999;20:773-783.
ABSTRACT | FULL TEXT  

Cynomolgus Polyoma Virus Infection : A New Member of the Polyoma Virus Family Causes Interstitial Nephritis, Ureteritis, and Enteritis in Immunosuppressed Cynomolgus Monkeys
van Gorder et al.
Am. J. Pathol. 1999;154:1273-1284.
ABSTRACT | FULL TEXT  

Cell and Molecular Biology of Simian Virus 40: Implications for Human Infections and Disease
Butel and Lednicky
JNCI J Natl Cancer Inst 1999;91:119a-134a.
ABSTRACT | FULL TEXT  

Simian virus 40 and human pleural mesothelioma
Mulatero et al.
Thorax 1999;54:60-61.
ABSTRACT | FULL TEXT  

The JC and BK human polyoma viruses appear to be recent introductions to some South American Indian tribes: There is no serological evidence of cross-reactivity with the simian polyoma virus SV40
Major and Neel
Proc. Natl. Acad. Sci. USA 1998;95:15525-15530.
ABSTRACT | FULL TEXT  

Simian Virus 40-Contaminated Polio Vaccine and Cancer Rates
Innis et al.
JAMA 1998;280:1481-1482.
FULL TEXT  

SV40-Contaminated Poliovirus Vaccine and Childhood Cancer Risk
Gross Fisher et al.
JAMA 1998;279:1527-1528.
FULL TEXT  

Simian Virus 40-Contaminated Poliovirus Vaccine and Cancer
JWatch Infect. Diseases 1998;1998:12-12.
FULL TEXT  

CONTAMINATED POLIO VACCINE EXONERATED
JWatch General 1998;1998:6-6.
FULL TEXT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1998 American Medical Association. All Rights Reserved.