This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (17)  • Contact me when this article is cited  Related Content  • Related articles  • Similar articles in JAMA  Topic Collections  • Viral Infections  • Gastroenterology  • Liver/ Biliary Tract/ Pancreatic Diseases  • Infectious Diseases  • Alert me on articles by topic  Social Bookmarking   What's this?

Diane S. Lauderdale, PhD; Ronda J. Oram, MD; Karen P. Goldstein, MD, MPH; Robert S. Daum, MD

JAMA. 1999;282:1725-1730.

Context  In 1991, the Advisory Committee on Immunization Practices recommended universal vaccination of infants against hepatitis B virus (HBV), with series initiation within days of birth.

Objective  To determine HBV vaccine coverage in a low-income urban population and to examine whether HBV immunization within the first month of life affects subsequent vaccine receipt.

Design  Cohort study based on immunization records collected in the Pediatric Immunization Program.

Setting  Large public housing development in Chicago, Ill.

Participants  All 1143 children who were born between 1991 and 1997 and enrolled between 1993 and mid-1998, with follow-up to age 35 months.

Main Outcome Measures  On-time vaccine receipt of HBV vaccine doses, diphtheria-tetanus-pertussis vaccine (DTP) dose 1, and the 4:3:1 series (4 doses of DTP vaccine, 3 doses of poliomyelitis vaccine, and 1 dose of measles-containing vaccine), analyzed by year.

Results  On-time HBV vaccination increased quickly following new guidelines and reached a plateau of about 50% coverage for those born in or after 1995. Since 1994, more children (64%) received the first HBV vaccine dose on time than any other vaccine. Children who received a dose of HBV vaccine during their first month of life were more likely to receive the first DTP vaccine dose on time (60.1%) than those who did not get an HBV vaccine dose during the first month (36.4%; ² = 53.7; P<.001). Children who received the first HBV vaccine dose during their first month were more likely than those receiving it at age 1 to 2 months to complete 3 HBV doses by 19 months (70.6% vs 51.1%; ² = 11.6; P = .001) and to complete the 4:3:1 series by age 19 months (49.8% vs 37.9%; ² = 4.0; P = .05).

Conclusions  In this inner-city population, HBV vaccine has been received at rates similar to those of other vaccines within 3 years of issuance of new recommendations. Of note, immunization with HBV vaccine at birth was associated with timely receipt of other vaccines and, therefore, may have the potential to increase vaccination among groups less likely to be up-to-date on early childhood vaccines.

Author Affiliations: Departments of Health Studies (Dr Lauderdale) and Pediatrics (Drs Oram, Goldstein, and Daum), University of Chicago, Chicago, Ill.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

RELATED ARTICLES

Limiting Infant Exposure to Thimerosal in Vaccines and Other Sources of Mercury
Neal A. Halsey
JAMA. 1999;282(18):1763-1766.
EXTRACT | FULL TEXT  

November 10, 1999
JAMA. 1999;282(18):1787-1788.
EXTRACT | FULL TEXT  

Prevent hepatitis B infection
JAMA. 1999;282(18):1790.
PDF  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

On-Time Immunization Rates Among Children Who Enter Chicago Public Schools
Dominguez et al.
Pediatrics 2004;114:e741-e747.
ABSTRACT | FULL TEXT  

Impact of Thimerosal-Related Changes in Hepatitis B Vaccine Birth-Dose Recommendations on Childhood Vaccination Coverage
Luman et al.
JAMA 2004;291:2351-2358.
ABSTRACT | FULL TEXT  

Hepatitis B Vaccination for Newborns
Cantekin et al.
JAMA 2001;286:535-536.
FULL TEXT  

What Happened to Primum Non Nocere?
Seal and Daum
Pediatrics 2001;107:1177-1178.
FULL TEXT  

Impact of Recommendations to Suspend the Birth Dose of Hepatitis B Virus Vaccine
Oram et al.
JAMA 2001;285:1874-1879.
ABSTRACT | FULL TEXT  

Variation in Clinician Recommendations for Multiple Injections During Adoption of Inactivated Polio Vaccine
Lieu et al.
Pediatrics 2001;107:e49-e49.
ABSTRACT | FULL TEXT  

Association Between Administration of Hepatitis B Vaccine at Birth and Completion of the Hepatitis B and 4:3:1:3 Vaccine Series
Yusuf et al.
JAMA 2000;284:978-983.
ABSTRACT | FULL TEXT  

Effect of a Monetary Sanction on Immunization Rates of Recipients of Aid to Families With Dependent Children
Kerpelman et al.
JAMA 2000;284:53-59.
ABSTRACT | FULL TEXT  

Resume hep B immunization at birth: AAP
Pickering
AAP News 2000;16:1-7.
FULL TEXT  

Limiting Infant Exposure to Thimerosal in Vaccines and Other Sources of Mercury
Halsey
JAMA 1999;282:1763-1766.
FULL TEXT