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Measles History and Atopic Diseases
A Population-Based Cross-sectional Study
Mikko Paunio, MD, MHS;
Olli P. Heinonen, MD, DSc;
Martti Virtanen, MD, MSc;
Pauli Leinikki, MD, PhD;
Annamari Patja, MD;
Heikki Peltola, MD, DTM&H
JAMA. 2000;283:343-346.
Context Many recent cross-sectional studies have suggested that lack of early exposure to communicable diseases, including measles, in affluent countries may have increased rates of atopic disease.
Objective To study the association between natural measles infection and atopy.
Design and Setting Cross-sectional nationwide study in Finland using data gathered between November 1, 1982, and June 30, 1986.
Subjects A total of 547,910 individuals aged 14 months to 19 years who at the time of measles-mumps-rubella (MMR) vaccination had relevant information collected on the occurrence of measles and allergic rhinitis, eczema, and asthma.
Main Outcome Measures Lifetime occurrence of atopic manifestations in subjects who had had measles compared with those who had not, expressed as age-specific and age-adjusted prevalence ratios.
Results The age-adjusted prevalence ratio of atopic manifestations among those who had had measles (n = 20,690) compared with those who had not (n = 527,220) was 1.32 (95% confidence interval [CI], 1.27-1.36) for eczema, 1.41 (95% CI, 1.33-1.49) for rhinitis, and 1.67 (95% CI, 1.54-1.79) for asthma. The positive association between measles and atopy was evident at all ages, in both urban and rural dwellers, and among subjects with many or few contacts at home or in day care.
Conclusions Based on our data, measles and atopy occur more frequently together than expected, which does not support the hypothesis that experiencing natural measles infection offers protection against atopic disease.
Author Affiliations: Department of Public Health, University of Helsinki (Drs Paunio and Heinonen), Department of Hospital Services, Association of Local and Regional Authorities (Dr Virtanen), Department of Infectious Diseases, National Public Health Institute (Dr Leinikki), and Hospital for Children and Adolescents, Helsinki University Central Hospital (Drs Patja and Peltola), Helsinki, Finland.
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